Toll-Like Receptors (Tlrs) in Cancer; With an Extensive Focus on Tlr Agonists and Antagonists

Toll-Like Receptors (Tlrs) in Cancer; With an Extensive Focus on Tlr Agonists and Antagonists Publisher Pubmed

Keshavarz A¹ ; Pourbagherisigaroodi A¹ ; Zafari P^{2, 3} ; Bagheri N⁴ ; Ghaffari SH⁵ ; Bashash D¹

Source: IUBMB Life Published:2021

Abstract

At the forefront of the battle against pathogens or any endogenously released molecules, toll-like receptors (TLRs) play an important role as the most noble pattern recognition receptors. The ability of these receptors in distinguishing “self” and “non-self” antigens is a cornerstone in the innate immunity system; however, misregulation links inflammatory responses to the development of human cancers. It has been known for some time that aberrant expression and regulation of TLRs not only endows cancer cells an opportunity to escape from the immune system but also supports them through enhancing proliferation and angiogenesis. Over the past decades, cancer research studies have witnessed a number of preclinical and clinical breakthroughs in the field of TLR modulators and some of the agents have exceptionally performed well in advanced clinical trials. In the present review, we have provided a comprehensive review of different TLR agonists and antagonists and discuss their limitations, toxicities, and challenges to outline their future incorporation in cancer treatment strategies. © 2020 International Union of Biochemistry and Molecular Biology

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Style	Citing Format
MLA	Keshavarz A, et al.. "Toll-Like Receptors (Tlrs) in Cancer; With an Extensive Focus on Tlr Agonists and Antagonists." IUBMB Life, vol. 73, no. 1, 2021, pp. 10-25.
APA	Keshavarz A, Pourbagherisigaroodi A, Zafari P, Bagheri N, Ghaffari SH, Bashash D (2021). Toll-Like Receptors (Tlrs) in Cancer; With an Extensive Focus on Tlr Agonists and Antagonists. IUBMB Life, 73(1), 10-25.
Chicago	Keshavarz A, Pourbagherisigaroodi A, Zafari P, Bagheri N, Ghaffari SH, Bashash D. "Toll-Like Receptors (Tlrs) in Cancer; With an Extensive Focus on Tlr Agonists and Antagonists." IUBMB Life 73, no. 1 (2021): 10-25.
Harvard	Keshavarz A et al. (2021) 'Toll-Like Receptors (Tlrs) in Cancer; With an Extensive Focus on Tlr Agonists and Antagonists', IUBMB Life, 73(1), pp. 10-25.
Vancouver	Keshavarz A, Pourbagherisigaroodi A, Zafari P, Bagheri N, Ghaffari SH, Bashash D. Toll-Like Receptors (Tlrs) in Cancer; With an Extensive Focus on Tlr Agonists and Antagonists. IUBMB Life. 2021;73(1):10-25.
BibTex	@article{ author = {Keshavarz A and Pourbagherisigaroodi A and Zafari P and Bagheri N and Ghaffari SH and Bashash D}, title = {Toll-Like Receptors (Tlrs) in Cancer; With an Extensive Focus on Tlr Agonists and Antagonists}, journal = {IUBMB Life}, volume = {73}, number = {1}, pages = {10-25}, year = {2021} }
RIS	TY - JOUR AU - Keshavarz A AU - Pourbagherisigaroodi A AU - Zafari P AU - Bagheri N AU - Ghaffari SH AU - Bashash D TI - Toll-Like Receptors (Tlrs) in Cancer; With an Extensive Focus on Tlr Agonists and Antagonists JO - IUBMB Life VL - 73 IS - 1 SP - 10 EP - 25 PY - 2021 ER -

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