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Curcumin: A Modulator of Inflammatory Signaling Pathways in the Immune System Publisher Pubmed



Kahkhaie KR1, 2 ; Mirhosseini A3 ; Aliabadi A4 ; Mohammadi A5 ; Mousavi MJ6, 7 ; Haftcheshmeh SM8 ; Sathyapalan T9 ; Sahebkar A10, 11, 12
Authors
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Authors Affiliations
  1. 1. Department of Medical Biochemistry, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
  2. 2. Medicinal Plants Research Center, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
  3. 3. Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  6. 6. Department of Immunology and Allergy, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  7. 7. Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medical Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 91766-99199, Iran
  9. 9. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, HU3 2JZ, United Kingdom
  10. 10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 91779-48564, Iran

Source: Inflammopharmacology Published:2019


Abstract

Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. On the other hand, the role of inflammatory signaling pathways has been highlighted in the pathogenesis of several inflammatory diseases, and signaling molecules involved in these pathways are considered as valuable targets for new treatment approaches. We aimed to provide a comprehensive overview of the modulatory effects of curcumin on inflammatory signaling pathways which leads to inhibition of inflammation in different types of immune cells and animal models. In this comprehensive review, we elaborate on how curcumin can effectively inhibit multiple signaling molecules involved in inflammation including NF-κB, JAKs/STATs, MAPKs, β-catenin, and Notch-1. © 2019, Springer Nature Switzerland AG.
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