Green Formulation of Curcumin Loaded Lipid-Based Nanoparticles As a Novel Carrier for Inhibition of Post-Angioplasty Restenosis

Green Formulation of Curcumin Loaded Lipid-Based Nanoparticles As a Novel Carrier for Inhibition of Post-Angioplasty Restenosis Publisher Pubmed

Akhlaghi S¹ ; Rabbani S² ; Alavi S¹ ; Alinaghi A³ ; Radfar F² ; Dadashzadeh S¹ ; Haeri A^{1, 4}

Show Affiliations

1. Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
3. School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia
4. Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Materials Science and Engineering C Published:2019

Abstract

Restenosis is one of the major complications affecting outcomes of percutaneous coronary interventions. The aims of this study were to formulate curcumin (CUR) nanoparticles by using only lipidic ingredients in the absence of any organic solvent and to determine key formulation parameters using 2-level factorial design. CUR nanoparticles were prepared using triglyceride and egg phosphatidylcholine (EPC) by high-pressure homogenization (HPH) and fully characterized regarding drug loading, particle size, zeta potential, stability, drug release profile, conductivity, viscosity, refractive index, stability, morphology and FTIR analysis. The efficacy of CUR nanoparticles in inhibiting restenosis was investigated in a rat carotid artery model. Balloon-injured rats were randomly assigned to two control (saline and empty carrier) groups and CUR nanoparticle treated group. Arterial restenosis was assessed by histomorphometric, immunohistochemical and CT angiography analyses. Optimized CUR nanoparticles with almost 70% drug entrapment, an average particle size of 58 nm, PDI < 0.2, spherical nanostructures and sustained release profile were prepared. In morphometric analysis, neointimal area and neointima/media ratio significantly decreased in the animal group received CUR nanoparticles compared with control groups. Expression of Ki67 was markedly lower in the CUR nanoformulation group. CT angiograms confirmed patency of the artery in this group. These results suggest that the new strategy of intramural delivery of CUR lipid-based nanoparticles can be considered as a novel approach to prevent neointimal hyperplasia. © 2019 Elsevier B.V.

Style	Citing Format
MLA	Akhlaghi S, et al.. "Green Formulation of Curcumin Loaded Lipid-Based Nanoparticles As a Novel Carrier for Inhibition of Post-Angioplasty Restenosis." Materials Science and Engineering C, vol. 105, no. , 2019, pp. -.
APA	Akhlaghi S, Rabbani S, Alavi S, Alinaghi A, Radfar F, Dadashzadeh S, Haeri A (2019). Green Formulation of Curcumin Loaded Lipid-Based Nanoparticles As a Novel Carrier for Inhibition of Post-Angioplasty Restenosis. Materials Science and Engineering C, 105(), -.
Chicago	Akhlaghi S, Rabbani S, Alavi S, Alinaghi A, Radfar F, Dadashzadeh S, Haeri A. "Green Formulation of Curcumin Loaded Lipid-Based Nanoparticles As a Novel Carrier for Inhibition of Post-Angioplasty Restenosis." Materials Science and Engineering C 105, no. (2019): -.
Harvard	Akhlaghi S et al. (2019) 'Green Formulation of Curcumin Loaded Lipid-Based Nanoparticles As a Novel Carrier for Inhibition of Post-Angioplasty Restenosis', Materials Science and Engineering C, 105(), pp. -.
Vancouver	Akhlaghi S, Rabbani S, Alavi S, Alinaghi A, Radfar F, Dadashzadeh S, et al.. Green Formulation of Curcumin Loaded Lipid-Based Nanoparticles As a Novel Carrier for Inhibition of Post-Angioplasty Restenosis. Materials Science and Engineering C. 2019;105():-.
BibTex	@article{ author = {Akhlaghi S and Rabbani S and Alavi S and Alinaghi A and Radfar F and Dadashzadeh S and Haeri A}, title = {Green Formulation of Curcumin Loaded Lipid-Based Nanoparticles As a Novel Carrier for Inhibition of Post-Angioplasty Restenosis}, journal = {Materials Science and Engineering C}, volume = {105}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Akhlaghi S AU - Rabbani S AU - Alavi S AU - Alinaghi A AU - Radfar F AU - Dadashzadeh S AU - Haeri A TI - Green Formulation of Curcumin Loaded Lipid-Based Nanoparticles As a Novel Carrier for Inhibition of Post-Angioplasty Restenosis JO - Materials Science and Engineering C VL - 105 IS - SP - EP - PY - 2019 ER -

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