Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration?

Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration? Publisher Pubmed

Shirooie S¹ ; Nabavi SF^{2, 3} ; Dehpour AR^{4, 5} ; Belwal T⁶ ; Habtemariam S⁷ ; Arguelles S⁸ ; Sureda A⁹ ; Daglia M¹⁰ ; Tomczyk M¹¹ ; Sobarzosanchez E^{12, 13} ; Xu S¹⁴ ; Nabavi SM³

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1. Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
2. Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
3. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, 14359-16471, Iran
4. Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
6. G.B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi Katarmal, Almora, Uttarakhand, India
7. Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Chatham-Maritime, ME4 4TB, Kent, United Kingdom
8. Department of Physiology, Faculty of Pharmacy, University of Seville, Seville, Spain
9. Research Group on Community Nutrition and Oxidative Stress (NUCOX) and CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), University of Balearic Islands, Palma de Mallorca E-07122, Balearic Islands, Spain
10. Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy
11. Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Bialystok, ul. Mickiewicza 2a, Bialystok, 15-230, Poland
12. Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Spain
13. Instituto de Investigacion en Innovacion en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago, Chile
14. Aab Cardiovascular Research Institute, University of Rochester, Rochester, 14623, NY, United States

Source: Pharmacological Research Published:2018

Abstract

Neurodegenerative diseases (NDs) such as Parkinson's (PD), Alzheimer's (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) cause significant world-wide morbidity and mortality. To date, there is no drug of cure for these, mostly age-related diseases, although approaches in delaying the pathology and/or giving patients some symptomatic relief have been adopted for the last few decades. Various studies in recent years have shown the beneficial effects of omega-3 poly unsaturated fatty acids (PUFAs) through diverse mechanisms including anti-inflammatory effects. This review now assesses the potential of this class of compounds in NDs therapy through specific action against the mammalian target of rapamycin (mTOR) signaling pathway. The role of mTOR in neurodegenerative diseases and targeted therapies by PUFAs are discussed. © 2018 Elsevier Ltd

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Style	Citing Format
MLA	Shirooie S, et al.. "Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration?." Pharmacological Research, vol. 135, no. , 2018, pp. 37-48.
APA	Shirooie S, Nabavi SF, Dehpour AR, Belwal T, Habtemariam S, Arguelles S, Sureda A, Daglia M, Tomczyk M, Sobarzosanchez E, Xu S, Nabavi SM (2018). Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration?. Pharmacological Research, 135(), 37-48.
Chicago	Shirooie S, Nabavi SF, Dehpour AR, Belwal T, Habtemariam S, Arguelles S, Sureda A, et al.. "Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration?." Pharmacological Research 135, no. (2018): 37-48.
Harvard	Shirooie S et al. (2018) 'Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration?', Pharmacological Research, 135(), pp. 37-48.
Vancouver	Shirooie S, Nabavi SF, Dehpour AR, Belwal T, Habtemariam S, Arguelles S, et al.. Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration?. Pharmacological Research. 2018;135():37-48.
BibTex	@article{ author = {Shirooie S and Nabavi SF and Dehpour AR and Belwal T and Habtemariam S and Arguelles S and Sureda A and Daglia M and Tomczyk M and Sobarzosanchez E and Xu S and Nabavi SM}, title = {Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration?}, journal = {Pharmacological Research}, volume = {135}, number = {}, pages = {37-48}, year = {2018} }
RIS	TY - JOUR AU - Shirooie S AU - Nabavi SF AU - Dehpour AR AU - Belwal T AU - Habtemariam S AU - Arguelles S AU - Sureda A AU - Daglia M AU - Tomczyk M AU - Sobarzosanchez E AU - Xu S AU - Nabavi SM TI - Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration? JO - Pharmacological Research VL - 135 IS - SP - 37 EP - 48 PY - 2018 ER -

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