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Target Genes Used for Biosensor Development in Covid-19 Diagnosis Publisher Pubmed



Zandi M1, 2 ; Fani M3
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathobiology & Laboratory Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

Source: Biosensors and Bioelectronics Published:2022


Abstract

In a published review entitled “COVID-19 diagnosis —A review of current methods”, the authors considered hemagglutinin esterase as one of the structural proteins of SARS-CoV-2 and also they did not represent ORF3b, ORF9b, and ORF9c in SARS-CoV-2 genome structure. However, according to the scientific evidence, among coronaviruses only some betacoronaviruses (Embecovirus subgenera) contain HE, and the genome of most of the coronaviruses such as SARS-CoV-2, SARS-CoV, and MERS-CoV lack the HE gene. In addition, the genome of SARS-CoV-2 contains several accessory proteins ORFs including ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c, and ORF10. © 2021 Elsevier B.V.
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