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Synthesis and Evaluation of Coumarin-Resveratrol Hybrids As 15-Lipoxygenaze Inhibitors Publisher



Rahmaninezhad S1 ; Khosravani L1 ; Saeedi M2 ; Divsalar K3 ; Firoozpour L4 ; Pourshojaei Y1 ; Sarrafi Y5 ; Nadri H6 ; Moradi A6 ; Mahdavi M1 ; Shafiee A1 ; Foroumadi A3, 4
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
  6. 6. Department of Medicinal Chemistry, Faculty of Pharmacy and Neurobiomedical Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Synthetic Communications Published:2015


Abstract

A series of coumarin-resveratrol hybrids, 3-arylcoumarin derivatives 3a-u, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo[2.2.2]octane under solvent-free conditions. All the synthesized compounds were screened for their inhibitory potency against soybean 15-lipoxygenase. Among them, three compounds (3c, 3j, and 3q) showed good enzyme-inhibitory activities. GRAPHICAL ABSTRACT. Copyright © 2015 Taylor & Francis Group, LLC.
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