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Base-Promoted One-Pot Strategy for Expeditious Assembly of Highly Functionalized Benzocoumarin Derivatives Publisher



Rakaee F1 ; Shiri M1 ; Farajpour B1 ; Majedi S2 ; Seraj M1 ; Moradkhani F3 ; Taheri S4 ; Sadeghidolatabadi MR1 ; Majedi S2
Authors

Source: Journal of Organic Chemistry Published:2024


Abstract

A versatile and atom-economic three-component reaction between 3-cyano-4-styrylcoumarins, 1,3-indandione, and aliphatic alcohols is described for synthesizing diversely multifunctionalized benzocoumarins. This strategy allows facile access to various benzocoumarins bearing an amine and a substituted benzoyl scaffold under simple heating conditions. Readily available precursors, operational simplicity, acceptable functional group tolerance, and excellent yields are some highlighted advantages of this transformation. © 2024 American Chemical Society.
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