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Mirna-Related Polymorphisms in Mir-146A and Tcf21 Are Associated With Increased Susceptibility to Coronary Artery Disease in an Iranian Population Publisher Pubmed



Bastami M1 ; Ghaderian SMH2 ; Omrani MD2 ; Mirfakhraie R1 ; Vakili H3 ; Parsa SA3 ; Narimansalehfam Z4 ; Masotti A5
Authors
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Authors Affiliations
  1. 1. Medical Genetics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 666677951, Iran
  3. 3. Cardiovascular Research Center, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Medical Genetics Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Bambino Gesu Children's Hospital-IRCCS, Gene Expression - Microarrays Laboratory, Rome, Italy

Source: Genetic Testing and Molecular Biomarkers Published:2016


Abstract

Aims: Recent studies have suggested that single-nucleotide polymorphisms (SNPs) in miRNA genes or their binding sites may alter an individual's susceptibility to coronary artery disease (CAD). In the present study, the association between two such SNPs (rs2910164 in miR-146a and rs12190287, which disrupts miRNA binding to TCF21) and CAD, in an Iranian population, was evaluated and in silico analyses were conducted to predict disease-related effects of miR-146a rs2910164. Methods: The study population consisted of angiographically confirmed CAD patients (n = 300) and asymptomatic controls (n = 300). Genotyping was performed using the TaqMan genotyping assay. Results: A multivariate regression analysis revealed that rs2910164 was associated with an increased CAD risk in the dominant model. In comparison to GG homozygotes, individuals who carry at least one C allele had a significantly higher risk of CAD (GC+CC vs. GG, odds ratios [OR]: 1.82, 95% confidence intervals [CI]: 1.18-2.80, p = 6.358e-3). Similarly, TCF21 rs12190287 was observed to be associated with CAD in a log-additive model (OR: 0.63, 95% CI: 0.45-0.88, p = 6.584e-3). An in silico analysis revealed that rs2910164 may modify the miR-146a-3p-mediated regulation of several biological processes that are implicated in CAD, like those that are related to the regulation of apoptosis and immune response. Conclusions: Our data provide the first evidence for the association of miR-146a rs2910164 and TCF21 rs12190287 with CAD in an Iranian population, encouraging further research to elucidate the disease-related effects of miR-146a rs2910164. © Copyright 2016, Mary Ann Liebert, Inc. 2016.
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