Critical Roles of Mir-21 in Promotions Angiogenesis: Friend or Foe? Publisher Pubmed



Saadh MJ¹ ; Jasim NY² ; Ahmed MH³ ; Ballal S⁴ ; Kumar A^{5, 6} ; Atteri S⁷ ; Vashishth R⁸ ; Rizaev J⁹ ; Alhili A¹⁰ ; Jawad MJ¹¹ ; Yazdi F¹² ; Salajegheh A¹³ ; Akhavansigari R^{14, 15} Show Affiliations
Source: Clinical and Experimental Medicine Published:2025

Abstract

MiRNAs are small RNA strands that are managed following transcription and are of substantial importance in blood vessel formation. It is essential to oversee the growth, differentiation, death, movement and construction of tubes by angiogenesis-affiliated cells. If miRNAs are not correctly regulated in regard to angiogenesis, it can deteriorate the health and lead to various illnesses, which include cancer, cardiovascular disorder, critical limb ischemia, Crohn’s disease, ocular diseases, diabetic microvascular complications, and more. Consequently, it is vital to understand the crucial part that miRNAs play in the development of blood vessels, so we can develop reliable treatment plans for vascular diseases. This write-up will assess the critical role of miR-21/exosomal miR-21 in managing angiogenesis associated with bone growth, wound recovery, and other pathological conditions like tumor growth, ocular illnesses, diabetes, and other diseases connected to formation of blood vessels. Previous investigations have demonstrated that miR-21 is present at higher amounts in certain cancerous cells, and it influences a multitude of genes that moderate the increased creation of blood vessels. Furthermore, studies demonstrated that exosomal miR-21 has the capacity to interact with endothelial cells to foster tumor angiogenesis. For that reason, this review explains the critical importance of miR-21/exosomal miR-21 in managing both healthy and diseased states of angiogenesis. © The Author(s) 2025.