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Electrochemical Determination of Methyldopa by Graphene Quantum Dot / 1-Butyl-3-Methylimidazolium Hexafluoro Phosphate Nanocomposite Electrode Publisher



Sanati AL1 ; Faridbod F1, 2
Authors
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Authors Affiliations
  1. 1. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  2. 2. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Electrochemical Science Published:2017


Abstract

Methyldopa is one the important catecholamines used for treatment of high blood pressure. In this study, a nanocomposite electrode was made using graphene quantum dots (GQD) and 1-butyl-3-methylimidazolium hexafluorophosphate (1B3MIPF6) in a carbon paste matrix (GQD/1B3MIPF6/CPE). The used GQD was synthesized and characterized using transmission electron microscopy (TEM). The electro-oxidation behavior of Methyldopa was investigated on the surface of GQD/1B3MIPF6/CPE and finally it was used as a working electrode for the electrochemical determination of Methyldopa in some pharmaceutical and biological samples. The results showed an improvement of ~3.2 times in electro-oxidation peak of methyldopa in a dynamic linear range of 0.04-750.0 μM (limit of detection 0.01 μM). © 2017 The Authors.
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