Association Between Hbv Infection and Colorectal Cancer in Iranian Population

Association Between Hbv Infection and Colorectal Cancer in Iranian Population

Tameshkel FS¹ ; Niya MHK^{1, 2} ; Panahi M^{1, 6} ; Alemrajabi M³ ; Tajik Z⁴ ; Roshanzamir N⁵ ; Ajdarkos H¹ ; Zamani F¹ ; Bouzari B⁶ ; Keyvani H^{1, 6}

Show Affiliations

1. Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran
2. Department of Virology, Iran University of Medical Sciences, Tehran, Iran
3. Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran
4. Department of Microbiology, Faculty of Basic Science, Qom Branch, Azad University, Qom, Iran
5. Department of Biology, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Pathology and Laboratory Sciences, Iran University of Medical Sciences, Tehran, Iran

Source: Govaresh Published:2020

Abstract

Background: Colorectal cancer (CRC) as a major health problem has increased globally. The etiology of CRC is among the critical issues. Smoking, obesity, and infectious diseases are probable risk factors of CRC. Meanwhile, chronic infections, such as chronic hepatitis B (CHB) is under investigation. Objectives: The aim of the present study was to determine the rate of HBV genome infection in patients with CRC compared with healthy subjects' colon tissues. Materials and Methods: Archived formalin-fixed paraffin-embedded (FFPE) blocks of 157 patients who underwent total colonoscopy that were referred to hospitals affiliated to Iran University of Medical Sciences, Tehran, Iran, were enrolled. They were categorized into 66 CRC cases and healthy colon tissues as the control group. After DNA extraction from FFPE specimens a Syber Green Real-time polymerase chain reaction (PCR) method was carried out. SPSS software version 16 was used for statistical analysis. Results: Of a total of 157 specimens, the mean age ± std. deviation of 66 patients with CRC was 59.3 ± 14.4, and 57.6% (38.66) of them were males. The mean age ± std. deviation of 91 healthy controls was 57.2 ± 14.6, and 57.1% (52) of them were males. By using real-time PCR we found that there were 6.4% (10.157) HBV positive, of them 9% (6.66) had CRC, and 4.4% (4.91) were healthy controls. Different variables did no t have any significant differences. Conclusion: Although some studies reported the association between HBV infection and CRC outcome, we could not prove it. It suggests the role of other risk factors in colorectal cancer incidence. Further studies with larger sample size and different study populations are recommended. © 2020 Iranian Association of Gastroenterology and Hepatology. All rights reserved.

Style	Citing Format
MLA	Tameshkel FS, et al.. "Association Between Hbv Infection and Colorectal Cancer in Iranian Population." Govaresh, vol. 25, no. 3, 2020, pp. 229-234.
APA	Tameshkel FS, Niya MHK, Panahi M, Alemrajabi M, Tajik Z, Roshanzamir N, Ajdarkos H, Zamani F, Bouzari B, Keyvani H (2020). Association Between Hbv Infection and Colorectal Cancer in Iranian Population. Govaresh, 25(3), 229-234.
Chicago	Tameshkel FS, Niya MHK, Panahi M, Alemrajabi M, Tajik Z, Roshanzamir N, Ajdarkos H, Zamani F, Bouzari B, Keyvani H. "Association Between Hbv Infection and Colorectal Cancer in Iranian Population." Govaresh 25, no. 3 (2020): 229-234.
Harvard	Tameshkel FS et al. (2020) 'Association Between Hbv Infection and Colorectal Cancer in Iranian Population', Govaresh, 25(3), pp. 229-234.
Vancouver	Tameshkel FS, Niya MHK, Panahi M, Alemrajabi M, Tajik Z, Roshanzamir N, et al.. Association Between Hbv Infection and Colorectal Cancer in Iranian Population. Govaresh. 2020;25(3):229-234.
BibTex	@article{ author = {Tameshkel FS and Niya MHK and Panahi M and Alemrajabi M and Tajik Z and Roshanzamir N and Ajdarkos H and Zamani F and Bouzari B and Keyvani H}, title = {Association Between Hbv Infection and Colorectal Cancer in Iranian Population}, journal = {Govaresh}, volume = {25}, number = {3}, pages = {229-234}, year = {2020} }
RIS	TY - JOUR AU - Tameshkel FS AU - Niya MHK AU - Panahi M AU - Alemrajabi M AU - Tajik Z AU - Roshanzamir N AU - Ajdarkos H AU - Zamani F AU - Bouzari B AU - Keyvani H TI - Association Between Hbv Infection and Colorectal Cancer in Iranian Population JO - Govaresh VL - 25 IS - 3 SP - 229 EP - 234 PY - 2020 ER -

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