Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Cfim25 and Alternative Polyadenylation: Conflicting Roles in Cancer Publisher Pubmed



Jafari Najaf Abadi MH1 ; Shafabakhsh R2 ; Asemi Z2 ; Mirzaei HR3 ; Sahebnasagh R4 ; Mirzei H2 ; Hamblin MR5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom Street, Boston, 02114, MA, United States

Source: Cancer Letters Published:2019


Abstract

Alternative polyadenylation (APA) is now widely recognized to regulate gene expression. APA is an RNA-processing mechanism that generates distinct 3′ termini on mRNAs, producing mRNA isoforms. Different factors influence the initiation and development of this process. CFIm25 (among others) is a cleavage and polyadenylation factor that plays a key role in the regulation of APA. Shortening of the 3′UTRs on mRNAs leads to enhanced cellular proliferation and tumorigenicity. One reason may be the up-regulation of growth promoting factors, such as Cyclin D1. Different studies have reported a dual role of CFIm25 in cancer (both oncogenic and tumor suppressor). microRNAs (miRNAs) may be involved in CFIm25 function as well as competing endogenous RNAs (ceRNAs). The present review focuses on the role of CFIm25 in cancer, cancer treatment, and possible involvement in other human diseases. We highlight the involvement of miRNAs and ceRNAs in the function of CFIm25 to affect gene expression. The lack of understanding of the mechanisms and regulation of CFIm25 and APA has underscored the need for further research regarding their role in cancer and other diseases. © 2019
Related Docs
1. Involved Micrornas in Alternative Polyadenylation Intervene in Breast Cancer Via Regulation of Cleavage Factor “Cfim25”, Scientific Reports (2020)
2. Poly(A) Tale: From a to A; Rna Polyadenylation in Prokaryotes and Eukaryotes, Wiley Interdisciplinary Reviews: RNA (2024)
3. Alternative Polyadenylation Mechanism Links Secreted Phosphoprotein 1 Gene to Glioblastoma, Cancer Biomarkers (2022)
4. Gynecologic Cancers and Non-Coding Rnas: Epigenetic Regulators With Emerging Roles, Critical Reviews in Oncology/Hematology (2021)
5. Overexpression of Microrna-16 Declines Cellular Growth, Proliferation and Induces Apoptosis in Human Breast Cancer Cells, In Vitro Cellular and Developmental Biology - Animal (2015)
Experts (# of related papers)
Hamid Reza Mirzaei (1)