Advancements in Nanotechnology Applications for Periodontal Surgery and Prosthetics in Maxillofacial Surgery Publisher



Bahadur KK ; Ghorbani M ; Ataei F ; Neyestanaki FJ ; Zare MS ; Namazikhah M ; Rezaeian S ; Fazel F
Source: Nanomedicine Research Journal Published:2025

Abstract

Periodontal and maxillofacial surgeries play crucial roles in restoring oral health and facial aesthetics; however, conventional techniques often face limitations in precision, biocompatibility, and long-term outcomes. Recent advancements in nanotechnology have introduced innovative approaches that significantly enhance treatment efficacy and patient outcomes in these fields. Nanocoatings on titanium and ceramic implants improve osseointegration and reduce bacterial colonization, thereby increasing implant stability and longevity. Furthermore, the development of nanofiber and nanocomposite scaffolds, alongside additive manufacturing technologies, has revolutionized tissue regeneration and prosthetic reconstruction, enabling personalized and durable solutions for complex craniofacial defects. Despite promising results, the safe clinical translation of nanomaterials requires ongoing research addressing biocompatibility, long-term safety, and regulatory challenges. This review highlights key breakthroughs in nanotechnology enabled drug delivery, diagnostics, and tissue engineering, underscoring their transformative potential in periodontal and maxillofacial surgery, while advocating for interdisciplinary collaboration to overcome translational barriers and facilitate routine clinical adoption. © 2025 Elsevier B.V., All rights reserved.