Viewpoint: Origin of Sars-Cov-2 Publisher Pubmed



Lundstrom K¹ ; Seyran M^{2, 3} ; Pizzol D⁴ ; Adadi P⁵ ; Elaziz TMA^{6, 7} ; Hassan SS⁸ ; Soares A⁶ ; Kandimalla R^{9, 10} ; Tambuwala MM¹¹ ; Aljabali AAA¹² ; Azad GK¹³ ; Choudhury PP¹⁴ ; Uversky VN¹⁵ ; Sherchan SP¹⁶ Show All Authors Show Affiliations
Source: Viruses Published:2020

Abstract

The origin of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus causing the COVID-19 pandemic has not yet been fully determined. Despite the consensus about the SARS-CoV-2 origin from bat CoV RaTG13, discrepancy to host tropism to other human Coronaviruses exist. SARS-CoV-2 also possesses some differences in its S protein receptor-binding domain, glycan-binding N-terminal domain and the surface of the sialic acid-binding domain. Despite similarities based on cryo-EM and biochemical studies, the SARS-CoV-2 shows higher stability and binding affinity to the ACE2 receptor. The SARS-CoV-2 does not appear to present a mutational hot spotas only the D614G mutation has been identified from clinical isolates. As laboratory manipulation is highly unlikely for the origin of SARS-CoV-2, the current possibilities comprise either natural selection in animal host before zoonotic transfer or natural selection in humans following zoonotic transfer. In the former case, despite SARS-CoV-2 and bat RaTG13 showing 96% identity some pangolin Coronaviruses exhibit very high similarity to particularly the receptor-binding domain of SARS-CoV-2. In the latter case, it can be hypothesized that the SARS-CoV-2 genome has adapted during human-to-human transmission and based on available data, the isolated SARS-CoV-2 genomes derive from a common origin. Before the origin of SARS-CoV-2 can be confirmed additional research is required. © 2020 by the authors.