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The Spike Protein Mutations and Its Effect on Sars-Cov-2 Pathogenesis Publisher



Zandi M1, 2 ; Soltani S1, 2 ; Sanami S3 ; Rasooli A4, 5
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Department of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran
  5. 5. Virology Department, Pasteur Institute of Iran, Tehran, Iran

Source: Journal of Cellular and Molecular Anesthesia Published:2021


Abstract

The severe acute respiratory syndrome coronavirus 2 spike (S) glycoprotein facilitates receptor binding to initiate cell entry that is the critical initial step in the infection cycle. Due to S glycoprotein's pivotal role, in this review, we pointed to show potential functional and structural consequences of S glycoprotein and its variants, which has been related to increased viral load in humans with SARS-CoV-2 infection. © 2021 Journal of Cellular and Molecular Anesthesia. All rights reserved.
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