Synthesis and Biological Evaluation of 1,3,4,5-Tetrasubstituted Pyrazole Derivatives

Synthesis and Biological Evaluation of 1,3,4,5-Tetrasubstituted Pyrazole Derivatives Publisher

Yahyavi H^{1, 3} ; Hosseinzadeh F¹ ; Karimi N¹ ; Moghimi S¹ ; Mahdavi M² ; Nadri H⁴ ; Moradi A⁴ ; Shafiee A¹ ; Foroumadi A^{1, 2}

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1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Chemistry, Alzahra University, Tehran, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences Published:2016

Abstract

We report a solvent-free synthesis of novel 1,3,4,5-tetrasubstituted pyrazoles and investigate their inhibitory activity against soybean 15-lipoxygenase. It was revealed that all synthesized compounds exhibited good activity, and among them, 3-(furan-2-yl)-1,4,5-triphenyl-1H-pyrazole (5j) showed 10 times stronger inhibitory activity in comparison to the reference drug quercetin. © 2016, Verlag der Zeitschrift fur Naturforschung. All rights reserved.

Style	Citing Format
MLA	Yahyavi H, et al.. "Synthesis and Biological Evaluation of 1,3,4,5-Tetrasubstituted Pyrazole Derivatives." Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, vol. 71, no. 9, 2016, pp. 973-977.
APA	Yahyavi H, Hosseinzadeh F, Karimi N, Moghimi S, Mahdavi M, Nadri H, Moradi A, Shafiee A, Foroumadi A (2016). Synthesis and Biological Evaluation of 1,3,4,5-Tetrasubstituted Pyrazole Derivatives. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 71(9), 973-977.
Chicago	Yahyavi H, Hosseinzadeh F, Karimi N, Moghimi S, Mahdavi M, Nadri H, Moradi A, Shafiee A, Foroumadi A. "Synthesis and Biological Evaluation of 1,3,4,5-Tetrasubstituted Pyrazole Derivatives." Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences 71, no. 9 (2016): 973-977.
Harvard	Yahyavi H et al. (2016) 'Synthesis and Biological Evaluation of 1,3,4,5-Tetrasubstituted Pyrazole Derivatives', Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 71(9), pp. 973-977.
Vancouver	Yahyavi H, Hosseinzadeh F, Karimi N, Moghimi S, Mahdavi M, Nadri H, et al.. Synthesis and Biological Evaluation of 1,3,4,5-Tetrasubstituted Pyrazole Derivatives. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences. 2016;71(9):973-977.
BibTex	@article{ author = {Yahyavi H and Hosseinzadeh F and Karimi N and Moghimi S and Mahdavi M and Nadri H and Moradi A and Shafiee A and Foroumadi A}, title = {Synthesis and Biological Evaluation of 1,3,4,5-Tetrasubstituted Pyrazole Derivatives}, journal = {Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences}, volume = {71}, number = {9}, pages = {973-977}, year = {2016} }
RIS	TY - JOUR AU - Yahyavi H AU - Hosseinzadeh F AU - Karimi N AU - Moghimi S AU - Mahdavi M AU - Nadri H AU - Moradi A AU - Shafiee A AU - Foroumadi A TI - Synthesis and Biological Evaluation of 1,3,4,5-Tetrasubstituted Pyrazole Derivatives JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences VL - 71 IS - 9 SP - 973 EP - 977 PY - 2016 ER -

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