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The Critical Role of Faecalibacterium Prausnitzii in Human Health: An Overview Publisher Pubmed



Leylabadlo HE1, 2, 3 ; Ghotaslou R2, 4 ; Feizabadi MM5 ; Farajnia S6 ; Moaddab SY4 ; Ganbarov K7 ; Khodadadi E8 ; Tanomand A9 ; Sheykhsaran E2 ; Yousefi B10 ; Kafil HS1
Authors
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Authors Affiliations
  1. 1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Microbiology, Baku State University, Baku, Azerbaijan
  8. 8. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Microbiology, Maragheh University of Medical Sciences, Maragheh, Iran
  10. 10. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Microbial Pathogenesis Published:2020


Abstract

Faecalibacterium prausnitzii (F. prausnitzii) is one of the most abundant bacterial species in the colon of healthy human adults and representing more than 5% of the total bacterial population. Recently, it has been known as a major actor in human intestinal health and a biosensor. Changes in this species population richness and quantity have been observed in many illnesses and several investigations have reported that abundance of F. prausnitzii is reduced in different intestinal disorders. In the current review, we aim to consider literature from various library databases and electronic searches (Science Direct, PubMed, and Google Scholar) which were randomly collected and serve as an overview of different features of F. prausnitzii including metabolites, anti-inflammatory action, and correlation of dysbiosis of this bacterium with various complications in human. © 2020 Elsevier Ltd
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