Stroke Burden in North Africa and the Middle East, 1990-2021: An Analysis Based on the Global Burden of Disease Study Publisher Pubmed



P Fallahtafti PARISA ; A Habibzadeh AMIRHOSSEIN ; N Ghasemloo NEGAR ; A Ghanbari AMIN ; M Taebi MORVARID ; K Hosseini KAVEH ; H Soleimani HAMIDREZA
Source: BMC Neurology Published:2025

Abstract

Background and objective: This study provides updated estimates of stroke burden, risk factors, and their trends in North Africa and Middle East (NAME) region from 1990 to 2021, which are essential for effective healthcare and resource allocation. Methods: Data were obtained from the Global Burden of Disease (GBD) 2021 study, which provides comprehensive epidemiological estimates for stroke across 21 countries in the NAME super region. We calculated age-standardized rates for prevalence, incidence, mortality, and disability-adjusted life years (DALYs) using the GBD standard population. Decomposition analysis was conducted to assess the contributions of population growth, aging, and changes in age-specific incidence rates to the overall stroke burden. Results: There was a significant increase in absolute numbers of stroke cases, deaths, and DALYs in the NAME region from 1990 to 2021, with a total of 614,803.8 new stroke cases in 2021, representing a 101.2% increase since 1990. Despite this rise, age-standardized rates for incidence, mortality, and DALYs decreased significantly. High systolic blood pressure, air pollution, and high level of low-density lipoprotein cholesterol (LDL-C) were identified as the leading risk factors contributing to stroke mortality in the region in 2021. Conclusion: Stroke remains a pressing public health issue in the NAME region, marked by rising absolute case numbers but declining age-standardized rates. This trend may reflect improvements in stroke awareness, early detection, and medical advancements, though the extent varies across countries. Significant disparities exist, as lower-income nations face greater challenges in prevention, acute care, and rehabilitation compared to higher-income countries with better healthcare infrastructure. Addressing these gaps through targeted policies and resource allocation is crucial to improving stroke outcomes across the region. © 2025 Elsevier B.V., All rights reserved.