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Polydopamine Biomaterials for Skin Regeneration Publisher Pubmed



Yazdi MK1 ; Zare M2 ; Khodadadi A3 ; Seidi F1 ; Sajadi SM4, 5 ; Zarrintaj P6 ; Arefi A7 ; Saeb MR8 ; Mozafari M9
Authors
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Authors Affiliations
  1. 1. Jiangsu Co-Innovation Center Of Efficient Processing And Utilization Of Forest Resources, Joint International Research Lab Of Lignocellulosic Functional Materials, Nanjing Forestry University, Nanjing, 210037, China
  2. 2. Skin And Stem Cell Research Center, Tehran University Of Medical Sciences, Tehran, 141663-4793, Iran
  3. 3. Department Of Internal Medicine, School Of Medicine, Gonabad University Of Medical Sciences, Gonabad, 96914, Iran
  4. 4. Department Of Nutrition, Cihan University-Erbil, Kurdistan Region, Erbil, 44001, Iraq
  5. 5. Department Of Phytochemistry, Src, Soran University, Kurdistan Regional Government, Soran, 44008, Iraq
  6. 6. School Of Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, 74078, OK, United States
  7. 7. Department Of Chemical Engineering, McMaster University, Hamilton, L8S 4L8, ON, Canada
  8. 8. Department Of Polymer Technology, Faculty Of Chemistry, Gdansk University Of Technology, Narutowicza 11/12, Gdansk, 80-233, Poland
  9. 9. Department Of Tissue Engineering & Regenerative Medicine, Iran University Of Medical Sciences, Tehran, 144961-4535, Iran

Source: ACS Biomaterials Science and Engineering Published:2022


Abstract

Designing biomaterials capable of biomimicking wound healing and skin regeneration has been receiving increasing attention recently. Some biopolymers behave similarly to the extracellular matrix (ECM), supporting biointerfacial adhesion and intrinsic cellular interactions. Polydopamine (PDA) is a natural bioadhesive and bioactive polymer that endows high chemical versatility, making it an exciting candidate for a wide range of biomedical applications. Moreover, biomaterials based on PDA and its derivatives have near-infrared (NIR) absorption, excellent biocompatibility, intrinsic antioxidative activity, antibacterial activity, and cell affinity. PDA can regulate cell behavior by controlling signal transduction pathways. It governs the focal adhesion behavior of cells at the biomaterials interface. These features make melanin-like PDA a fascinating biomaterial for wound healing and skin regeneration. This paper overviews PDA-based biomaterials' synthesis, properties, and interactions with biological entities. Furthermore, the utilization of PDA nano- and microstructures as a constituent of wound-dressing formulations is highlighted. © 2022 American Chemical Society.
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