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Current Advances and Challenges in Covid-19 Vaccine Development: From Conventional Vaccines to Next-Generation Vaccine Platforms Publisher Pubmed



Jafari A1, 2 ; Danesh Pouya F3 ; Niknam Z2 ; Abdollahpouralitappeh M4, 5 ; Rezaeitavirani M2 ; Rasmi Y3, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  2. 2. Proteomics Research Center, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  4. 4. Cellular and Molecular Biology Research Center, Larestan University of Medical Sciences, Larestan, Iran
  5. 5. Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran
  6. 6. Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran

Source: Molecular Biology Reports Published:2022


Abstract

The world is grappling with an unprecedented public health crisis COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2. Due to the high transmission/mortality rates and socioeconomic impacts of the COVID-19, its control is crucial. In the absence of specific treatment, vaccines represent the most efficient way to control and stop the pandemic. Many companies around the world are currently making efforts to develop the vaccine to combat COVID-19. This review outlines key strategies for generating SARS-CoV-2 vaccine candidates, along with the mechanism of action, advantages, and potential limitations of each vaccine. The use of nanomaterials and nanotechnology for COVID-19 vaccines development will also be discussed. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.
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