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Safety and Effectiveness of High-Dose Vitamin C in Patients With Covid-19: A Randomized Open-Label Clinical Trial Publisher Pubmed



Jamalimoghadamsiahkali S1 ; Zarezade B2 ; Koolaji S3 ; Seyedalinaghi SA4 ; Zendehdel A5 ; Tabarestani M6 ; Sekhavati Moghadam E7 ; Abbasian L2 ; Dehghan Manshadi SA2 ; Salehi M2 ; Hasannezhad M2 ; Ghaderkhani S2 ; Meidani M2 ; Salahshour F8 Show All Authors
Authors
  1. Jamalimoghadamsiahkali S1
  2. Zarezade B2
  3. Koolaji S3
  4. Seyedalinaghi SA4
  5. Zendehdel A5
  6. Tabarestani M6
  7. Sekhavati Moghadam E7
  8. Abbasian L2
  9. Dehghan Manshadi SA2
  10. Salehi M2
  11. Hasannezhad M2
  12. Ghaderkhani S2
  13. Meidani M2
  14. Salahshour F8
  15. Jafari F2
  16. Manafi N9
  17. Ghiasvand F10

Source: European Journal of Medical Research Published:2021


Abstract

Background: Vitamin C is an essential water-soluble nutrient that functions as a key antioxidant and has been proven to be effective for boosting immunity. In this study, we aimed to assess the efficacy of adding high-dose intravenous vitamin C (HDIVC) to the regimens for patients with severe COVID-19 disease. Methods: An open-label, randomized, and controlled trial was conducted on patients with severe COVID-19 infection. The case and control treatment groups each consisted of 30 patients. The control group received lopinavir/ritonavir and hydroxychloroquine and the case group received HDIVC (6 g daily) added to the same regimen. Results: There were no statistically significant differences between two groups with respect to age and gender, laboratory results, and underlying diseases. The mean body temperature was significantly lower in the case group on the 3rd day of hospitalization (p = 0.001). Peripheral capillary oxygen saturations (SpO2) measured at the 3rd day of hospitalization was also higher in the case group receiving HDIVC (p = 0.014). The median length of hospitalization in the case group was significantly longer than the control group (8.5 days vs. 6.5 days) (p = 0.028). There was no significant difference in SpO2 levels at discharge time, the length of intensive care unit (ICU) stay, and mortality between the two groups. Conclusions: We did not find significantly better outcomes in the group who were treated with HDIVC in addition to the main treatment regimen at discharge. Trial registration irct.ir (IRCT20200411047025N1), April 14, 2020 © 2021, The Author(s).
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