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Β-Cyclodextrin Functionalized Poly (5-Amidoisophthalicacid) Grafted Fe3o4 Magnetic Nanoparticles: A Novel Biocompatible Nanocomposite for Targeted Docetaxel Delivery Publisher



Tarasi R1 ; Khoobi M2, 3 ; Niknejad H4 ; Ramazani A1 ; Mamani L5 ; Bahadorikhalili S3 ; Shafiee A3
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, Iran
  2. 2. Department of Pharmaceutical Biomaterials, Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Nanotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran

Source: Journal of Magnetism and Magnetic Materials Published:2016


Abstract

Thiol-lactam initiated radical polymerization (TLIRP) was successfully employed to prepare poly-N-5-acrylamidoisophthalicacid grafted onto Fe3O4 magnetic nanoparticles (MNPs@PAIP). β-Cyclodextrin (CD) was then conjugated to the carboxylic groups of the prepared MNPs via carbodiimide activation. Subsequently, tumor-targeting folic acid (FA) was attached to the hydroxyl groups of CD on the surface of the latter MNPs to increase the site-specific intracellular delivery. The prepared MNPs were fully characterized by FTIR, VSM, TGA, XRD, FE-SEM and TEM. Docetaxel (DTX) as hydrophobic anticancer drug was loaded via host-guest inclusion complexation with CD and the release profile of the system was studied at different pH. The effect of MNPs on the cell viability was evaluated for the human embryonic kidney normal cell line (HEK293) as well as HeLa and MDA-MB-231 cancerous cell lines and the results did not show any apparent cytotoxic effect. In comparison, DTX loaded MNPs reduced the growth of HeLa and MDA-MB-231 cells more than free DTX. Intracellular uptake ability of DTX loaded MNPs was also studied using fluorescent microscopy and showed cellular uptake about 90% after 4 h treatment. © 2016 Elsevier B.V. All rights reserved.
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