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Down-Regulation of Mir-122 After Transplantation of Mesenchymal Stem Cells in Acute Liver Failure in Mice Model Publisher Pubmed



Fathikazerooni M1 ; Kazemnejad S2 ; Khanjani S2 ; Saltanatpour Z1 ; Tavoosidana G1
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Authors Affiliations
  1. 1. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Source: Biologicals Published:2019


Abstract

This study investigated the correlation between the hepatic level of miR-122 and the extent of liver tissue regeneration in CCl 4 induced liver injury mice model following transplantation of menstrual blood-(MenSCs) and bone marrow-derived stem cells (BMSCs). Hepatic miR-122 levels were significantly up-regulated following administration of CCl 4 (P < 0.01). The significant positive correlations were observed between hepatic miR-122 and biochemical serum markers and the severity of liver injury in histopathological assessments (P < 0.01). Following stem cell therapy, all cell treated groups showed a significant down-regulation in miR-122 that was significantly correlated with improvement in histopathological features and biochemical markers (P < 0.01). Furthermore, the hepatic level of miR-122 was lower in the MenSCs-treated group compared with the BMSCs-treated group (P < 0.01) and in HPL cells-treated groups in reference to undifferentiated cells-treated groups (P < 0.05). These data suggest that miR-122 could be used as a potential predictor of outcome of liver injury after mesenchymal stem cell transplantation. © 2019 International Alliance for Biological Standardization
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