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The Promise of Regenerative Medicine in the Treatment of Urogenital Disorders Publisher Pubmed



Keshel SH1 ; Rahimi A1 ; Hancox Z2 ; Ebrahimi M2 ; Khojasteh A1 ; Sefat F2, 3
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biomedical and Electronics Engineering, School of Engineering, University of Bradford, Bradford, United Kingdom
  3. 3. Interdisciplinary Research Centre in Polymer Science & Technology (Polymer IRC), University of Bradford, Bradford, United Kingdom

Source: Journal of Biomedical Materials Research - Part A Published:2020


Abstract

Polymers and scaffolds are the most significant tools in regenerative medicine. Urogenital disorders are an important group of diseases that greatly affect the patient's life expectancy and quality. Reconstruction of urogenital defects is one of the current challenges in regenerative medicine. Regenerative medicine, as well as tissue engineering, may offer suitable approaches, while the tools needed are appropriate materials and cells. Autologous urothelial cells obtained from biopsy, bone marrow-derived stem cells, adipose stem cells and urine-derived stem cells that expressed mesenchymal cell markers are the cells that mainly used. In addition, two main types of biomaterials mainly exist; synthetic polymers and composite scaffolds that are biodegradable polymers with controllable properties and naturally derived biomaterials such as extracellular matrix components and acellular tissue matrices. In this review, we present and evaluate the most appropriate and suitable scaffolds (naturally derived and synthetic polymers) and cells applied in urogenital reconstruction. © 2020 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals, Inc.
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