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Implications of Micrornas in the Pathogenesis of Atherosclerosis and Prospects for Therapy Publisher Pubmed



Gorabi AM1 ; Ghanbari M2, 3 ; Sathyapalan T4 ; Jamialahmadi T5, 6 ; Sahebkar A7, 8, 9
Authors
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Authors Affiliations
  1. 1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, Netherlands
  3. 3. Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom
  5. 5. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran
  6. 6. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

Source: Current Drug Targets Published:2021


Abstract

MicroRNAs (miRNAs) are non-coding RNAs containing around 22 nucleotides, which are expressed in vertebrates and plants. They act as posttranscriptional gene expression regulators, fine-tuning various biological processes in different cell types. There is emerging evidence on their role in different stages of atherosclerosis. In addition to regulating the inflammatory cells involved in atherosclerosis, miRNAs play fundamental roles in the pathophysiology of atherosclerosis, such as endothelial cell (EC) dysfunction, the aberrant function of the vascular smooth muscle cell (VSMC) and cholesterol metabolism. Moreover, miRNAs participate in several pathogenic pathways of atherosclerotic plaque development, including their effects on immune cell signaling receptors and lipid uptake. In this study, we review our current knowledge of the regulatory role of miRNAs in various pathogenic pathways underlying atherosclerosis development and also outline potential clinical applications of miRNAs in atherosclerosis. © 2021 Bentham Science Publishers.
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