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Global Prevalence, Cascade of Care, and Prophylaxis Coverage of Hepatitis B in 2022: A Modelling Study Publisher Pubmed



Razavishearer DM1 ; Gamkrelidze I1 ; Pan CQ2 ; Jia J3 ; Berg T4 ; Gray RT5 ; Lim YS6 ; Chen CJ7 ; Ocama P8 ; Desalegn H9 ; Abbas Z10 ; Abdallah AR11, 12 ; Aghemo A13, 14 ; Ahmadbekova S15 Show All Authors
Authors
  1. Razavishearer DM1
  2. Gamkrelidze I1
  3. Pan CQ2
  4. Jia J3
  5. Berg T4
  6. Gray RT5
  7. Lim YS6
  8. Chen CJ7
  9. Ocama P8
  10. Desalegn H9
  11. Abbas Z10
  12. Abdallah AR11, 12
  13. Aghemo A13, 14
  14. Ahmadbekova S15
  15. Ahn SH16
  16. Aho I17
  17. Akarca US18
  18. Al Masri NM19
  19. Alalwan AM20
  20. Alavian SM21
  21. Albusafi SA22
  22. Aleman S23
  23. Alfaleh FZ24
  24. Alghamdi AS25
  25. Alhamoudi WK26
  26. Aljumah AA27
  27. Alnaamani K28
  28. Alrifai A29
  29. Alserkal YM30
  30. Altraif IH31
  31. Amarsanaa J32
  32. Anderson M33
  33. Andersson MI34
  34. Armstrong P35
  35. Asselah T36
  36. Athanasakis K37
  37. Baatarkhuu O38
  38. Benari Z39, 40
  39. Bensalem A41
  40. Bessone F42
  41. Biondi MJ43
  42. Bizri ARN44
  43. Blach S1
  44. Braga WSM45
  45. Brandaomello CE46, 47
  46. Brosgart CL48
  47. Brown KA49
  48. Bruggmann P51
  49. Brunetto MR52, 53
  50. Buti M54
  51. Cabezas J55, 56
  52. Casanovas T57
  53. Chae C58
  54. Chan HLY59
  55. Cheinquer H60
  56. Chen PJ61
  57. Cheng KJG62
  58. Cheon ME63
  59. Chien CH64
  60. Choudhuri G65
  61. Christensen PB66, 67
  62. Chuang WL68
  63. Chulanov V69
  64. Cisneros Garza LE70
  65. Coffin CS71
  66. Contreras FA72
  67. Coppola N73
  68. Cornberg M74
  69. Cowie B75
  70. Cramp ME76
  71. Craxi A77
  72. Crespo J78, 79
  73. Cui F80
  74. Cunningham CW81
  75. Dalgard O82
  76. De Knegt RJ83
  77. De Ledinghen V84
  78. Dore GJ5
  79. Drazilova S85
  80. Duberg AS86
  81. Egeonu S87
  82. Elbadri M88
  83. Elkassas M89
  84. Elsayed MH90
  85. Estes C1
  86. Etzion O91, 92
  87. Farag E93
  88. Ferradini L94
  89. Ferreira PRA95
  90. Flisiak R96
  91. Forns X97
  92. Frankova S98
  93. Fung J99
  94. Gane EJ100
  95. Garcia V101, 102, 103
  96. Garciasamaniego J104
  97. Gemilyan M105
  98. Genov J106
  99. Gheorghe LS107, 108
  100. Gholam PM109
  101. Gish RG110
  102. Goleij P111
  103. Gottfredsson M112, 113
  104. Grebely J5
  105. Gschwantler M114, 115
  106. Guingane NA116
  107. Hajarizadeh B5
  108. Hamid SS117
  109. Hamoudi W118
  110. Harris AM119
  111. Hasan I120
  112. Hatzakis A121
  113. Hellard ME122
  114. Hercun J123
  115. Hernandez J124
  116. Hockickova I125, 147
  117. Hsu YC126
  118. Hu CC127
  119. Husa P128, 129
  120. Janicko M85
  121. Janjua N130
  122. Jarcuska P85
  123. Jaroszewicz J131
  124. Jelev D132
  125. Jeruma A133, 134
  126. Johannessen A135
  127. Kaberg M136
  128. Kaita KDE137
  129. Kaliaskarova KS138
  130. Kao JH139
  131. Kellyhanku A5
  132. Khamis F140
  133. Khan AG141
  134. Kheir OO142
  135. Khoudri I143
  136. Kondili LA144, 145
  137. Konysbekova A146
  138. Kristian P125, 147
  139. Kwon JA5
  140. Lagging M148, 149
  141. Laleman W150, 151
  142. Lampertico P152
  143. Lavanchy D153
  144. Lazaro P154
  145. Lazarus JV155
  146. Lee AU156
  147. Lee MH157
  148. Liakina V158, 159
  149. Luksic B160
  150. Malekzadeh R161
  151. Malu AO162, 163
  152. Marinho RT164
  153. Mendescorrea MC165
  154. Merat S166
  155. Meshesha BR9
  156. Midgard H167
  157. Mohamed R168
  158. Mokhbat JE169
  159. Mooneyhan E1
  160. Moreno C170
  161. Mortgat L171
  162. Mullhaupt B172
  163. Musabaev E173
  164. Muyldermans G171
  165. Naveira MCM1
  166. Negro F174
  167. Nersesov AV175
  168. Nguyen VTT176
  169. Ning Q177, 178
  170. Njouom R179
  171. Ntagirabiri R180
  172. Nurmatov ZS181
  173. Oguche S182
  174. Omuemu CE183
  175. Ong JP184
  176. Oparesem OK185
  177. Ormeci N186
  178. Orrego M187, 188
  179. Osiowy C189
  180. Papatheodoridis GV190
  181. Peckradosavljevic M191
  182. Pessoa MG192
  183. Pham TND193
  184. Phillips RO194
  185. Pimenov N195
  186. Pincayrodriguez LDR196
  187. Plaseskakaranfilska D197
  188. Pop C198
  189. Poustchi H166
  190. Prabdialsing NN199
  191. Qureshi H200
  192. Ramji A201
  193. Rautiainen H202
  194. Razavishearer K1
  195. Remak WM203
  196. Ribeiro S204
  197. Ridruejo E205
  198. Rioshincapie CY206
  199. Robalino MC207
  200. Roberts LR208
  201. Roberts SK209
  202. Rodriguez M210
  203. Roulot D211
  204. Rwegasha J212
  205. Ryder SD213
  206. Sadirova S214
  207. Saeed U215, 216
  208. Safadi R217
  209. Sagalova O218
  210. Said SS219
  211. Salupere R220, 221
  212. Sanai FM222
  213. Sanchezavila JF223
  214. Saraswat VA224
  215. Sargsyants N225
  216. Sarrazin C226, 227
  217. Sarybayeva G228
  218. Schreter I229
  219. Seguindevaux C230
  220. Seto WK231, 232
  221. Shah SR233
  222. Sharara AI44
  223. Sheikh M166
  224. Shouval D217
  225. Sievert W234
  226. Simojoki K235
  227. Simonova MY236
  228. Sinn DH237
  229. Sonderup MW238
  230. Sonneveld MJ239
  231. Spearman CW238
  232. Sperl J98
  233. Stauber RE240
  234. Stedman CAM241
  235. Sypsa V242
  236. Tacke F243
  237. Tan SS244
  238. Tanaka J245
  239. Tergast TL74
  240. Terrault NA246
  241. Thompson AJ247
  242. Thompson PJ248
  243. Tolmane I249, 250
  244. Tomasiewicz K251
  245. Tsang TY252
  246. Uzochukwu BSC253, 254, 255
  247. Van Welzen B256
  248. Vanwolleghem T257
  249. Vince A258
  250. Voeller AS1
  251. Waheed Y259, 260
  252. Waked I261
  253. Wallace J262, 263, 264
  254. Wang C265
  255. Weis N266, 267
  256. Wong GLH268
  257. Wong VWS268
  258. Wu JC269, 270
  259. Yaghi CG271
  260. Yesmembetov K138, 272
  261. Yip TCF268
  262. Yosry A273
  263. Yu ML274, 275, 276
  264. Yuen MF277
  265. Yurdaydin C278
  266. Zeuzem S279
  267. Zuckerman E280
  268. Razavi HA1
Show Affiliations
Authors Affiliations
  1. 1. Center for Disease Analysis Foundation, Lafayette, CO, United States
  2. 2. Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health, NYU Grossman School of Medicine, New York, NY, United States
  3. 3. Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China
  4. 4. Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany
  5. 5. The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
  6. 6. Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
  7. 7. Genomics Research Center, Academia Sinica, Taipei, Taiwan
  8. 8. Makerere University, Kampala, Uganda
  9. 9. St Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia
  10. 10. Dr Ziauddin University Hospital, Karachi, Pakistan
  11. 11. National Liver Institute, Shebin Elkom, Egypt
  12. 12. Family and Community Medicine, College of Medicine, Taibah University, Almadinah, Saudi Arabia
  13. 13. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy
  14. 14. Department of Gastroenterology, Humanitas Research Hospital IRCCS, Rozzano, Italy
  15. 15. Particularly Dangerous Infections, SSES RT, Dushanbe, Tajikistan
  16. 16. Yonsei University College of Medicine, Seoul, South Korea
  17. 17. Helsinki University Hospital, Helsinki, Finland
  18. 18. Department of Gastroenterology, Medical School, Ege University, Izmir, Turkey
  19. 19. Department of Gastroenterology & Hepatology, Prince Sultan Medical Military City, Riyadh, Saudi Arabia
  20. 20. Department of Hepatobiliary Science and Liver Transplantation, King Abdulaziz Medical City, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
  21. 21. Baqiatallah Research Center for Gastroenterology and Liver Diseases, Baqiatallah University of Medical Sciences, Tehran, Iran
  22. 22. College of Medicine and Health Sciences, Sultan Qaboos University, AlKhoudh, Oman
  23. 23. Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
  24. 24. Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia
  25. 25. Gastroenterology Unit, Medical Department, King Fahad General Hospital, Jeddah, Saudi Arabia
  26. 26. Department of Medicine, King Saud University, Riyadh, Saudi Arabia
  27. 27. Department of Clinical Sciences, College of Medicine, Dar Al Uloom University, Riyadh, Saudi Arabia
  28. 28. Division of Gastroenterology and Hepatology, Armed Forces Hospital, Muscat, Oman
  29. 29. Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates
  30. 30. Emirates Health Services, Abu Dhabi, United Arab Emirates
  31. 31. Hepatology Division, Hepatobiliary Sciences and Organ Transplant Center, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
  32. 32. Otoch Manramba Medical University, Ulaanbaatar, Mongolia
  33. 33. Laboratory Department, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana
  34. 34. Nuffield Department of Clinical Laboratory Science, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
  35. 35. Division of Viral Hepatitis, US Centers for Disease Control and Prevention, Atlanta, GA, United States
  36. 36. Hepatology Department, University of Paris-Cite, Hopital Beaujon, AP-HP, INSERM UMR1149, Paris, France
  37. 37. Department of Public Health Policy, University of West Attica, Athens, Greece
  38. 38. Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  39. 39. Liver Diseases Center, Sheba Medical Center, Ramat Gan, Israel
  40. 40. Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
  41. 41. Hepatitis Virus Laboratory, Department of Virology, Pasteur Institute of Algeria, Algiers, Algeria
  42. 42. Facultad de Medicina, University of Rosario School of Medicine, Rosario, Argentina
  43. 43. School of Nursing, York University, Toronto, ON, Canada
  44. 44. American University of Beirut Medical Center, Beirut, Lebanon
  45. 45. Virology Department, Fundacao de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Brazil
  46. 46. University of Rio de Janeiro, Rio de Janeiro, Brazil
  47. 47. Clinica de Doencas do Figado, Rio de Janeiro, Brazil
  48. 48. Department of Medicine, Biostatistics and Epidemiology, UCSF, San Francisco, CA, United States
  49. 49. Department of Medicine, Henry Ford Hospital, Detroit, MI, United States
  50. 50. Weill Cornell Medicine, New York, NY, United States
  51. 51. Arud Centre for Addiction Medicine, Zurich, Switzerland
  52. 52. Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
  53. 53. Integrated Department of Medical Specialties, University Hospital of Pisa, Pisa, Italy
  54. 54. Liver Unit, Hospital Universitari Vall d Hebron, CIBEREHD, Insituto Carlos III, Universidad Autonoma de Barcelona, Barcelona, Spain
  55. 55. Gastroenterology and Hepatology Department, Marques de Valdecilla University Hospital, Santander, Spain
  56. 56. Clinical and Translational Research in Digestive Diseases, IDIVAL, Santander, Spain
  57. 57. ASSCAT, ELPA, Barcelona, Spain
  58. 58. Division of Risk Assessment, Korea Disease Control and Prevention Agency, Cheongju, South Korea
  59. 59. Faculty of Medicine, The Chinese University of Hong Kong, Department of Internal Medicine, Union Hospital, Hong Kong
  60. 60. Department of Gastroenterology and Hepatology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
  61. 61. Hepatitis Research Center, National Taiwan University, Taipei, Taiwan
  62. 62. Maxwell School of Citizenship and Public Affairs, Department of Social Science, Syracuse University, Syracuse, NY, United States
  63. 63. Division of HIV/AIDS Prevention and Control, Korea Disease Control and Prevention Agency, Cheongju, South Korea
  64. 64. Division of Hepato-Gastroenterology, Chang Gung Memorial Hospital Keelung Branch, Keelung, Taiwan
  65. 65. Department of Gastroenterology and Hepatology, Fortis Memorial Research Institute, Gurgaon, India
  66. 66. Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
  67. 67. Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
  68. 68. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
  69. 69. National Medical Research Center of Phthisiopulmonology & Infectious Diseases, Moscow, Russian Federation
  70. 70. Hospital Christus Muguerza Alta Especialidad, Monterrey Nuevo Leon, Mexico
  71. 71. Medicine/Microbiology and Infectious Diseases Department, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
  72. 72. Universidad Nacional Pedro Henriquez Urena, Santo Domingo, Dominican Republic
  73. 73. Mental Health and Public Medicine, University of Campania, Naples, Italy
  74. 74. Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
  75. 75. WHO Collaborating Centre for Viral Hepatitis, Doherty Institute, Melbourne, VIC, Australia
  76. 76. South West Liver Unit, University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom
  77. 77. PROMISE, School of Medicine, University of Palermo, Palermo, Italy
  78. 78. Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marques de Valdecilla University Hospital, Santander, Spain
  79. 79. School of Medicine, University of Cantabria, Santander, Spain
  80. 80. School of Public Health, Peking University, Beijing, China
  81. 81. Research Centre for Hauora & Health, Massey University, Wellington, New Zealand
  82. 82. Department of Infectious Diseases, Akershus University Hospital, Lorenskog, Norway
  83. 83. Erasmus MC University Medical Center, Rotterdam, Netherlands
  84. 84. Service d'Hepatologie et de Transplantation Hepatique, CHU, Bordeaux, France
  85. 85. 2nd Department of Internal Medicine, PJ Safarik University, Faculty of Medicine, L Pasteur University Hospital, Kosice, Slovakia
  86. 86. Department of Infectious Diseases, Faculty of Medicine and Health, Orebro University, Orebro, Sweden
  87. 87. Federal Medical Centre, Jalingo, Nigeria
  88. 88. Gastroenterology Department, Hamad Medical Corporation, Doha, Qatar
  89. 89. Endemic Medicine Department, Helwan University, Cairo, Egypt
  90. 90. Department of Pediatrics, Ain Shams University, Cairo, Egypt
  91. 91. Department of Gastroenterology and Liver Diseases, Soroka University Medical Center, Beersheva, Israel
  92. 92. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel
  93. 93. Health Protection & Communicable Diseases Division, Ministry of Public Health, Doha, Qatar
  94. 94. FHI360, EpiC Indonesia, Indonesia
  95. 95. Division of Infectious Disease, Federal University of Sao Paulo, Sao Paulo, Brazil
  96. 96. Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland
  97. 97. Liver Unit, Hospital Clinic, IDIBAPS, CIBEREHD, University of Barcelona, Barcelona, Spain
  98. 98. Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
  99. 99. The University of Hong Kong, Hong Kong
  100. 100. New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand
  101. 101. Universidad Autonoma de Santo Domingo, Santo Domingo, Dominican Republic
  102. 102. Centro Endoscopico Digestivo Integral, Santo Domingo, Dominican Republic
  103. 103. Dominican Republic Health Ministry, Santo Domingo, Dominican Republic
  104. 104. Liver Unit, Hospital Universitario La Paz, CIBERehd, IdiPAZ, Universidad Autonoma de Madrid, Madrid, Spain
  105. 105. Yerevan State Medical University, Yerevan, Armenia
  106. 106. Clinic of Gastroenterology, University Hospital Tsaritsa Yoanna-ISUL, Medical University-Sofia, Sofia, Bulgaria
  107. 107. Department of Gastroenterology & Hepatology, Carol Davila University of Medicine & Pharmacy, Bucharest, Romania
  108. 108. Department of Gastroenterology & Hepatology, Fundeni Clinical Institute, Bucharest, Romania
  109. 109. Case Western Reserve University, School of Medicine, Cleveland, OH, United States
  110. 110. Hepatitis B Foundation, Doylestown, PA, United States
  111. 111. Department of Genetics, Sana Institute of Higher Education, Sari, Iran
  112. 112. Landspitali University Hospital, Reykjavik, Iceland
  113. 113. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  114. 114. Department of Internal Medicine IV, Klinik Ottakring, Vienna, Austria
  115. 115. Sigmund Freud University, Vienna, Austria
  116. 116. Chu Bogodogo, Ouagadougou, Burkina Faso
  117. 117. Aga Khan University, Karachi, Pakistan
  118. 118. Gastroenterology & Hepatology Department, Ministry of Health, Royal Hospital, Amman, Jordan
  119. 119. Division of Health Informatics and Surveillance, Center for Surveillance, Epidemiology, and Laboratory Services, Atlanta, GA, United States
  120. 120. Division of Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  121. 121. National and Kapodistrian University of Athens, Medical School, Athens, Greece
  122. 122. Burnet Institute, Melbourne, VIC, Australia
  123. 123. Liver Unit, Centre Hospitalier de l'Universite de Montreal, Montreal, QC, Canada
  124. 124. Universidad del Magdalena, Magdalena, Santa Marta, Colombia
  125. 125. Department of Infectology and Travel Medicine, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia
  126. 126. Department of Medical Research, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan
  127. 127. Gastroenterology and Hepatology, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan
  128. 128. Department of Infectious Diseases, University Hospital Brno, Brno, Czech Republic
  129. 129. Department of Infectious Diseases, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic
  130. 130. BC Centre for Disease Control, Vancouver, BC, Canada
  131. 131. Department of Infectious Diseases and Hepatology, Medical University of Silesia, Katowice, Poland
  132. 132. Clinic of Gastroenterology, University Hospital St Ivan Rilski, Sofia, Bulgaria
  133. 133. Riga East University Hospital, Riga, Latvia
  134. 134. Faculty of Medicine, Riga Stradins University, Riga, Latvia
  135. 135. Vestfold Hospital Trust, Tonsberg, Norway
  136. 136. Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden
  137. 137. Section of Hepatology, University of Manitoba, Winnipeg, MB, Canada
  138. 138. National Research Oncology Center, Astana, Kazakhstan
  139. 139. Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
  140. 140. Royal Hospital, Muscat, Oman
  141. 141. Lady Reading Hospital, Peshawar, Pakistan
  142. 142. Research Department, National Center for Gastrointestinal and Liver Diseases, Khartoum, Sudan
  143. 143. Directorate of Epidemiology and Disease Control, Ministry of Health, Rabat, Morocco
  144. 144. National Center for Global Health, Istituto Superiore di Sanita, Rome, Italy
  145. 145. UniCamillus-Saint Camillus International University of Health Sciences, Rome, Italy
  146. 146. Republican Diagnostic Center, University Medical Center, Astana, Kazakhstan
  147. 147. Department of Infectology and Travel Medicine, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia
  148. 148. Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  149. 149. Department of Clinical Microbiology, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden
  150. 150. Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium
  151. 151. Medizinische Klinik B, University Klinik Munster, Munster, Germany
  152. 152. Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
  153. 153. Denges, Switzerland
  154. 154. Madrid, Spain
  155. 155. Barcelona Institute for Global Health, Hospital Clinic, University of Barcelona, Barcelona, Spain
  156. 156. Gastroenterology and Hepatology Department, Concord Repatriation General Hospital, University of Sydney, Concord, NSW, Australia
  157. 157. Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
  158. 158. Clinic of Gastroenterology, Nephrourology and Surgery, Institute of Clinical Medicine, Vilnius University, Faculty of Medicine, Vilnius, Lithuania
  159. 159. Department of Chemistry and Bioengineering, Vilnius Tech, Faculty of Fundamental Sciences, Vilnius, Lithuania
  160. 160. Clinical Department of Infectious Diseases, University of Split, School of Medicine, Clinical Hospital Center Split, Split, Croatia
  161. 161. Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  162. 162. Department of Medicine, Adoose Specialist Hospital, Makurdi, Nigeria
  163. 163. Benue State University, Makurdi, Nigeria
  164. 164. Centro Hospitalar Lisboa Norte, Medical School of Lisbon, Lisboa, Portugal
  165. 165. Department of Infectious Diseases, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
  166. 166. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  167. 167. Department of Gastroenterology, Oslo University Hospital, Oslo, Norway
  168. 168. University of Malaya, Kuala Lumpur, Malaysia
  169. 169. Department of Medicine, Lebanese American University, Gilbert and Rose Marie Chagoury School of Medicine, Beirut, Lebanon
  170. 170. Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
  171. 171. Sciensano, Brussels, Belgium
  172. 172. Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
  173. 173. Research Institute of Virology, Tashkent, Uzbekistan
  174. 174. University of Geneva, Geneva, Switzerland
  175. 175. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  176. 176. STI, World Health Organization, Country Office in Viet Nam, Hanoi, Viet Nam
  177. 177. Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  178. 178. Chinese Society of Infectious Disease, Chinese Medical Association, Beijing, China
  179. 179. Virology Department, Centre Pasteur du Cameroun, Yaounde, Cameroon
  180. 180. CHU Kamenge, University Of Burundi, Bujumbura, Burundi
  181. 181. Republican Scientific Practical Center of Viral Infections Control, Scientific and Production Association Preventive Medicine, Bishkek, Kyrgyzstan
  182. 182. University of Jos, Jos, Nigeria
  183. 183. Department of Medicine, University of Benin, Benin City, Nigeria
  184. 184. University of the Philippines College of Medicine, Manila, Philippines
  185. 185. Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
  186. 186. Department of Gastroenterology, Istanbul Health and Technology University, Istanbul, Turkey
  187. 187. Clinica Las Americas AUNA, Medellin, Colombia
  188. 188. Hepatology Department, Clinica Las Vegas Quiron, Medellin, Colombia
  189. 189. Viral Hepatitis and Bloodborne Pathogens Department, National Microbiology Lab, Public Health Agency of Canada, Winnipeg, MB, Canada
  190. 190. Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
  191. 191. Klinikum Klagenfurt am Worthersee, Klagenfurt am Worthersee, Austria
  192. 192. Division of Gastroenterology and Hepatology, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
  193. 193. University of Illinois at Chicago, Chicago, IL, United States
  194. 194. Kumasi Centre for Collaborative Research, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
  195. 195. Laboratory of Epidemiology of Infectious Diseases, National Medical Research Center of Phthisiopulmonology & Infectious Diseases, Moscow, Russian Federation
  196. 196. Pan American Health Organization Consultant, Quito, Ecuador
  197. 197. Research Centre for Genetic Engineering and Biotechnology Georgi D. Efremov, Macedonian Academy of Sciences and Arts, Skopje, North Macedonia
  198. 198. Internal Medicine and Gastroenterology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
  199. 199. Centre for Vaccines and Immunology, National Institute for Communicable Diseases, Johannesburg, South Africa
  200. 200. Focal Point Hepatitis, Ministry of National Health Services, Regulations and Coordination, Islamabad, Pakistan
  201. 201. Department of Medicine, University of British Columbia, Vancouver, BC, Canada
  202. 202. Helsinki University Hospital Abdominal Center, Helsinki, Finland
  203. 203. International Association of Hepatitis Task Forces, Petaluma, CA, United States
  204. 204. Department of International Health, Care and Public Health Research Institute, Maastricht University, Maastricht, Netherlands
  205. 205. Hepatology Section, Department of Medicine, Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno CEMIC, Ciudad Autonoma de Buenos Aires, Argentina
  206. 206. Direccion de Promocion y Prevencion, Ministerio de Salud y Proteccion Social, Bogota, Colombia
  207. 207. Ministerio Salud Publica, Ministerio de Salud, Quito, Ecuador
  208. 208. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States
  209. 209. The Alfred, Melbourne, VIC, Australia
  210. 210. Liver Unit, Division of Gastroenterology and Hepatology, Hospital Universitario Central de Asturias, Oviedo, Spain
  211. 211. APHP, Hopital Avicenne, Unite d'Hepatologie, Universite Sorbonne Paris Nord, Bobigny, France
  212. 212. Gastroenterology Unit, Muhimbili National Hospital, Dar Es Salaam, Tanzania
  213. 213. NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
  214. 214. The Research Institute of Virology, The Republican Specialized Scientific Practical Medical Center of Epidemiology, Microbiology, Infections and Parasitics Diseases, Tashkent, Uzbekistan
  215. 215. Clinical and Biomedical Research Centre, Multidisciplinary Lab., Foundation University School of Health Sciences, Foundation University, Islamabad, Pakistan
  216. 216. International Center of Medical Sciences Research, Islamabad, Pakistan
  217. 217. The Liver Institute, Hadassah Medical Organization, Jerusalem, Israel
  218. 218. Infectious Diseases Department, South Ural State Medical University (Clinic), Chelyabinsk, Russian Federation
  219. 219. State University of Zanzibar, Zanzibar, Tanzania
  220. 220. Department of Gastroenterology, Tartu University Hospital, Tartu, Estonia
  221. 221. Department of Internal Medicine, University of Tartu, Tartu, Estonia
  222. 222. King Abdulaziz Medical City, Jeddah, Saudi Arabia
  223. 223. Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, Mexico
  224. 224. Professor Vivek Saraswat Department of Gastroenterology, Mahatma Gandhi Medical College and Hospital, Jaipur, India
  225. 225. National Center for Infectious Diseases, Yerevan, Armenia
  226. 226. Medizinische Klinik 2, St Josefs-Hospital, Wiesbaden, Germany
  227. 227. Medizinische Klinik 1, Goethe-University, Frankfurt am Main, Germany
  228. 228. Department of Science and International Cooperation, Kazakh Science Center of Dermatology and Infectious Diseases, Almaty, Kazakhstan
  229. 229. Department of Infectology and Travel Medicine, Medical Faculty, PJ Safarik University, Kosice, Slovakia
  230. 230. Department of Infection and Immunity, Luxembourg Institute of Health, Esch sur Alzette, Luxembourg
  231. 231. School of Clinical Medicine, State Key Laboratory of Liver Research, The University of Hong Kong, Hong Kong
  232. 232. The University of HongKong, Shenzhen Hospital, Shenzhen, China
  233. 233. Institute of Liver Disease, HPB Surgery and Transplant, Global Hospitals, Mumbai, India
  234. 234. Monash Health, Clayton, VIC, Australia
  235. 235. University of Helsinki, Helsinki, Finland
  236. 236. HPB Surgery and Transplantology, Military Medical Academy, Sofia, Bulgaria
  237. 237. Samsung Medical Center, Seoul, South Korea
  238. 238. Division of Hepatology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
  239. 239. Erasmus MC, Rotterdam, Netherlands
  240. 240. Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria
  241. 241. Gastroenterology Department, Christchurch Hospital, Christchurch, New Zealand
  242. 242. Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece
  243. 243. Department of Hepatology & Gastroenterology, Charite Universitatsmedizin Berlin, Berlin, Germany
  244. 244. Selayang Hospital, Batu Caves, Selangor, Malaysia
  245. 245. Hiroshima University, Hiroshima, Japan
  246. 246. Keck Medicine of University of Southern California, Los Angeles, CA, United States
  247. 247. Department of Gastroenterology, St Vincent's Hospital, The University of Melbourne, Melbourne, VIC, Australia
  248. 248. UNC Chapel Hill, Chapel Hill, NC, United States
  249. 249. Hepatology Department, Riga East University Hospital, Latvian Center of Infectious Diseases, Riga, Latvia
  250. 250. Faculty of Medicine, University of Latvia, Riga, Latvia
  251. 251. Department of Infectious Disease, Medical University of Lublin, Lublin, Poland
  252. 252. Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong, Hong Kong
  253. 253. Community Medicine Department, University of Nigeria Nsukka, Enugu, Nigeria
  254. 254. University of Nigeria Teaching Hospital Enugu, Enugu, Nigeria
  255. 255. Health Policy Research Group, University of Nigeria Nsukka, Enugu, Nigeria
  256. 256. University Medical Center Utrecht, Utrecht, Netherlands
  257. 257. Laboratory of Experimental Medicine and Pediatrics, Viral Hepatitis Prevention Board, University of Antwerp, Antwerp, Belgium
  258. 258. Medical School University of Zagreb, University Hospital of Infectious Diseases, Zagreb, Croatia
  259. 259. Office of Research, Innovation & Commercialization, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan
  260. 260. Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon
  261. 261. National Liver Institute, Shebeen El Kom, Egypt
  262. 262. Viral Hepatitis Elimination, Burnet Institute, CEVHAP, Melbourne, VIC, Australia
  263. 263. Australian Research Centre in Sex, Health and Society, Latrobe University, Melbourne, VIC, Australia
  264. 264. Centre for Social Research in Health, University of New South Wales, Sydney, NSW, Australia
  265. 265. Department of Medicine, Vanderbilt University, Nashville, TN, United States
  266. 266. Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
  267. 267. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  268. 268. Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
  269. 269. Institute of Clinical Medicine, National Yang Ming Chao Tung University, Taipei, Taiwan
  270. 270. Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan
  271. 271. Hotel Dieu de France University Hospital, Beirut, Lebanon
  272. 272. Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
  273. 273. Faculty of Medicine, Cairo University, Cairo, Egypt
  274. 274. School of Medicine, College of Medicine, Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-Sen University, Kaohsiung, Taiwan
  275. 275. Hepatobiliary Section, Department of Internal Medicine, Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
  276. 276. School of Medicine and Hepatitis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  277. 277. Department of Medicine, School of Clinical Medicine, Department and State Key Laboratory of Liver Research, Queen Mary Hospital, The University of Hong Kong, Hong Kong
  278. 278. Department of Gastroenterology and Hepatology, Koc University Medical School, Istanbul, Turkey
  279. 279. Department of Medicine, University Hospital, Frankfurt, Germany
  280. 280. Liver Unit, Carmel Medical Center, Faculty of Medicine, Technion Institute of Technology, Haifa, Israel

Source: The Lancet Gastroenterology and Hepatology Published:2023


Abstract

Background: The 2016 World Health Assembly endorsed the elimination of hepatitis B virus (HBV) infection as a public health threat by 2030; existing therapies and prophylaxis measures make such elimination feasible, even in the absence of a virological cure. We aimed to estimate the national, regional, and global prevalence of HBV in the general population and among children aged 5 years and younger, as well as the rates of diagnosis, treatment, prophylaxis, and the future burden globally. Methods: In this modelling study, we used a Delphi process with data from literature reviews and interviews with country experts to quantify the prevalence, diagnosis, treatment, and prevention measures for HBV infection. The PRoGReSs Model, a dynamic Markov model, was used to estimate the country, regional, and global prevalence of HBV infection in 2022, and the effects of treatment and prevention on disease burden. The future incidence of morbidity and mortality in the absence of additional interventions was also estimated at the global level. Findings: We developed models for 170 countries which resulted in an estimated global prevalence of HBV infection in 2022 of 3·2% (95% uncertainty interval 2·7–4·0), corresponding to 257·5 million (216·6–316·4) individuals positive for HBsAg. Of these individuals, 36·0 million were diagnosed, and only 6·8 million of the estimated 83·3 million eligible for treatment were on treatment. The prevalence among children aged 5 years or younger was estimated to be 0·7% (0·6–1·0), corresponding to 5·6 million (4·5–7·8) children with HBV infection. Based on the most recent data, 85% of infants received three-dose HBV vaccination before 1 year of age, 46% had received a timely birth dose of vaccine, and 14% received hepatitis B immunoglobulin along with the full vaccination regimen. 3% of mothers with a high HBV viral load received antiviral treatment to reduce mother-to-child transmission. Interpretation: As 2030 approaches, the elimination targets remain out of reach for many countries under the current frameworks. Although prevention measures have had the most success, there is a need to increase these efforts and to increase diagnosis and treatment to work towards the elimination goals. Funding: John C Martin Foundation, Gilead Sciences, and EndHep2030. © 2023 Elsevier Ltd
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