Biological Materials Introduced to the Market for Blurred Cornea Regeneration

Biological Materials Introduced to the Market for Blurred Cornea Regeneration Publisher

Boroumand S¹ ; Hamedi E¹ ; Sigaroodi F¹ ; Rahmani M¹ ; Ghassemi H² ; Maymand MM³ ; Khani MM¹

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1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. SinaCell Research and Production Co, Tehran, Iran

Source: Regenerative Engineering and Translational Medicine Published:2023

Abstract

Purpose: Corneal diseases are the fourth reason for blindness around the world which can be treated with corneal transplantation as a gold standard approach. However, alternative strategies get more valuable to peruse due to the challenges of donor shortage and failing the corneal transplantation procedure. This study aims to find the trend of biological products introduced to the market for corneal regeneration. Methods: Biological products introduced by different companies were evaluated in this review. The available and underevaluation products introduced to market are reported in this review. This search was done by keywords related to corneal/product, corneal/biological scaffold, corneal/biological product, corneal/allograft, corneal/xenograft, eye drops, biological eye drops, and amniotic membrane/cornea. Results: Decellularized products of xenogeneic or allogeneic cornea and amniotic membrane matrixes were mostly employed as corneal scaffold. In addition, biological eye drops, gels, and (platelet-rich plasma) PRP are used in several reports as bioactive ingredients. Conclusion: Herein, the most important issue about biological products that researchers are involved in is preserving the most active ingredients after decellularization or extraction process with minimum modification along with reasonable final cost. Lay Summary: Although at first glance cornea appears as simple avascular collagenous tissue, corneal diseases are the fourth leading cause of blindness according to the WHO reports. Currently, corneal transplantation has been chosen as a gold standard treatment. In recent years, the rising growth of smart biomaterials can be considered as a turning point in modern medicine by using smart scaffolds, a hydrogel with self-healing properties that could be potentially loaded with a drug, autologous cells, or stem cells. Here, we review available and under evaluation products introduced to the market to some extent overcome the cornea transplantation side effects. © 2023, The Author(s), under exclusive licence to The Regenerative Engineering Society.

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Style	Citing Format
MLA	Boroumand S, et al.. "Biological Materials Introduced to the Market for Blurred Cornea Regeneration." Regenerative Engineering and Translational Medicine, vol. , no. , 2023, pp. -.
APA	Boroumand S, Hamedi E, Sigaroodi F, Rahmani M, Ghassemi H, Maymand MM, Khani MM (2023). Biological Materials Introduced to the Market for Blurred Cornea Regeneration. Regenerative Engineering and Translational Medicine, (), -.
Chicago	Boroumand S, Hamedi E, Sigaroodi F, Rahmani M, Ghassemi H, Maymand MM, Khani MM. "Biological Materials Introduced to the Market for Blurred Cornea Regeneration." Regenerative Engineering and Translational Medicine , no. (2023): -.
Harvard	Boroumand S et al. (2023) 'Biological Materials Introduced to the Market for Blurred Cornea Regeneration', Regenerative Engineering and Translational Medicine, (), pp. -.
Vancouver	Boroumand S, Hamedi E, Sigaroodi F, Rahmani M, Ghassemi H, Maymand MM, et al.. Biological Materials Introduced to the Market for Blurred Cornea Regeneration. Regenerative Engineering and Translational Medicine. 2023;():-.
BibTex	@article{ author = {Boroumand S and Hamedi E and Sigaroodi F and Rahmani M and Ghassemi H and Maymand MM and Khani MM}, title = {Biological Materials Introduced to the Market for Blurred Cornea Regeneration}, journal = {Regenerative Engineering and Translational Medicine}, volume = {}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Boroumand S AU - Hamedi E AU - Sigaroodi F AU - Rahmani M AU - Ghassemi H AU - Maymand MM AU - Khani MM TI - Biological Materials Introduced to the Market for Blurred Cornea Regeneration JO - Regenerative Engineering and Translational Medicine VL - IS - SP - EP - PY - 2023 ER -

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