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The Colorful World of Carotenoids: A Profound Insight on Therapeutics and Recent Trends in Nano Delivery Systems Publisher Pubmed



Maghsoudi S1 ; Taghavi Shahraki B1 ; Rabiee N2 ; Fatahi Y3, 4, 5 ; Bagherzadeh M2 ; Dinarvand R3, 4 ; Ahmadi S6, 7 ; Rabiee M8 ; Tahriri M9 ; Hamblin MR10, 11 ; Tayebi L12 ; Webster TJ13
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Shiraz University of Technology, Shiraz, Iran
  2. 2. Department of Chemistry, Sharif University of Technology, Tehran, Iran
  3. 3. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Universal Scientific Education and Research Network (USERN), Tehran, Iran
  6. 6. Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  9. 9. Department of Developmental Sciences, Marquette University, Milwaukee, WI, United States
  10. 10. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States
  11. 11. Department of Dermatology, Harvard Medical School, Boston, United States
  12. 12. Department of Engineering, Norfolk State University, Norfolk, VA, United States
  13. 13. Department of Chemical Engineering, Northeastern University, Boston, MA, United States

Source: Critical Reviews in Food Science and Nutrition Published:2022


Abstract

The therapeutic effects of carotenoids as dietary supplements to control or even treat some specific diseases including diabetic retinopathy, cardiovascular diseases, bacterial infections, as well as breast, prostate, and skin cancer are discussed in this review and also thoughts on future research for their widespread use are emphasized. From the stability standpoint, carotenoids have low bioavailability and bioaccessibility owing to their poor water solubility, deterioration in the presence of environmental stresses such as oxygen, light, and high heat as well as rapid degradation during digestion. Nanoencapsulation technologies as wall or encapsulation materials have been increasingly used for improving food product functionality. Nanoencapsulation is a versatile process employed for the protection, entrapment, and the delivery of food bioactive products including carotenoids from diverse environmental conditions for extended shelf lives and for providing controlled release. Therefore, we present here, recent (mostly during the last five years) nanoencapsulation methods of carotenoids with various nanocarriers. To us, this review can be considered as the first highlighting not only the potential therapeutic effects of carotenoids on various diseases but also their most effective nanodelivery systems.Highlights Bioactive compounds are of deep interest to improve food properties. Carotenoids (such as β-carotene and xanthophylls) play indispensable roles in maintaining human health and well-being. A substantial research effort has been carried out on developing beneficial nanodelivery systems for various carotenoids. Nanoencapsulation of carotenoids can enhance their functional properties. Stable nanoencapsulated carotenoids could be utilized in food products. © 2021 Taylor & Francis Group, LLC.
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