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The Prevention of Cisplatin-Induced Nephrotoxicity: A General Consensus Statement of a Group of Oncologist-Hematologists, Adult and Pediatric Nephrologists, Radiation Oncologists, Clinical Pathologists, Clinical Pharmacologists, and Renal Physiologists on Cisplatin Therapy in Cancer Patients Publisher



Ashrafi F1, 2 ; Mortazavi M3, 4 ; Nematbakhsh M1, 5, 6
Authors
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Authors Affiliations
  1. 1. Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Internal Medicine, Oncology-Hematology Section, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Internal Medicine, Nephrology Section, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran

Source: International Journal of Preventive Medicine Published:2022


Abstract

Backgrounds: Most of the cancer patients with solid tumor are subjected to chemotherapy with cisplatin (CP) in clinic. However, the most side effect of CP is nephrotoxicity, which limits the treatment. The aim of study was to develop a general consensus statement for CP therapy in clinic to limit the drug-induced nephrotoxicity. Methods: A total of 30 oncologist-hematologists, adult and pediatric nephrologists, radiation oncologists, clinical pathologist clinical pharmacologist, and renal physiologist participated in a workshop, and in order to reduce the incidence of CP-induced nephrotoxicity, a general consensus was developed. Results: The developed general consensus was focused on some items such as age, sex, female hormone, nonsteroidal anti-inflammatory drugs (NSAID), renin-angiotensin system inhibitor drugs, glomerular filtration rate, hydration methods, contrasts, antioxidants, dextrose, and magnesium. Conclusion: The agreement between participants for CP therapy in clinic was achieved, and this general consensus was announced to be implemented in the hospitals. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
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