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Dietary and Lifestyle Indices for Hyperinsulinemia and Colorectal Cancer Risk: A Case-Control Study Publisher Pubmed



Sicahni PH1 ; Makhtoomi M2, 3 ; Leilami K3, 4 ; Shateri Z5 ; Mohammadi F3, 4 ; Nouri M1, 2, 6 ; Omidbeigi N7 ; Mehrabani S7 ; Rashidkhani B8
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Sciences, Nutrition and Food Security Research Center, Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Nutrition and Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
  6. 6. Health Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  7. 7. Department of Clinical Nutrition, School of Nutrition and Food Sciences, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: BMC Gastroenterology Published:2023


Abstract

Background: The incidence of colorectal cancer (CRC) has increased in Iran, and determining the dietary patterns that can contribute to reducing or increasing the risk of CRC will help better control this disease. Therefore, in the current study, we assessed the association between the empirical lifestyle index for hyperinsulinemia (ELIH) and the empirical dietary index for hyperinsulinemia (EDIH) with the CRC odds. Methods: The present case (n = 71)-control (n = 142) study was carried out in several CRC surgical units of hospitals in Tehran, Iran. A semi-quantitative food frequency questionnaire containing 168 items was used to assess participants’ dietary intakes. The EDIH and ELIH scores were calculated by food groups and some variables such as body mass index and physical activity. Logistic regression models were applied to evaluate the association between the EDIH and ELIH scores with CRC odds. Results: According to baseline features of the study participants, there were significant differences between the controls and cases in ELIH score, fiber intake, taking aspirin, and family history of CRC in first- and second-degree relatives. Also, we found that the odds of CRC increased significantly in the last tertile compared to the first tertile in EDIH and ELIH in the adjusted model (odds ratio (OR) = 3.12; 95% confidence interval (CI): 1.30–7.48 and OR = 4.72; 95% CI: 1.15–19.39, respectively). Conclusions: In conclusion, the result of this study indicated that CRC odds was significantly greater in subjects with higher EDIH and ELIH scores. Also, according to the results of this study, lifestyle and diet with insulinemic potential can influence the CRC risk. © 2023, The Author(s).
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