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Smart Mxene Quantum Dot-Based Nanosystems for Biomedical Applications Publisher



Iravani S1 ; Varma RS2
Authors
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Authors Affiliations
  1. 1. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University in Olomouc, Slechtitelu 27, Olomouc, 783 71, Czech Republic

Source: Nanomaterials Published:2022


Abstract

MXene quantum dots (QDs), with their unique structural, optical, magnetic, and electronic characteristics, are promising contenders for various pharmaceutical and biomedical appliances including biological sensing/imaging, cancer diagnosis/therapy, regenerative medicine, tissue engi-neering, delivery of drugs/genes, and analytical biochemistry. Although functionalized MXene QDs have demonstrated high biocompatibility, superb optical properties, and stability, several challenging issues pertaining to their long-term toxicity, histopathology, biodistribution, biodegradability, and photoluminescence properties are still awaiting systematic study (especially the move towards the practical and clinical phases from the pre-clinical/lab-scale discoveries). The up-scalable and optimized synthesis methods need to be developed not only for the MXene QD-based nanosystems but also for other smart platforms and hybrid nanocomposites encompassing MXenes with vast clinical and biomedical potentials. Enhancing the functionalization strategies, improvement of synthesis methods, cytotoxicity/biosafety evaluations, enriching the biomedical applications, and exploring additional MXene QDs are crucial aspects for developing the smart MXene QD-based nanosystems with improved features. Herein, recent developments concerning the biomedical applications of MXene QDs are underscored with emphasis on current trends and future prospects. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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