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Effect of Phentolamine As Reversal of Soft-Tissue Anesthesia on Post-Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial Publisher



Shadmehr E1 ; Saatchi M2 ; Sarmast ND3 ; Abtahi RS4 ; Davoudi A5
Authors
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Authors Affiliations
  1. 1. Department of Endodontics and Periodontics, Division of Endodontics, School of Dentistry, University of California, San Francisco, United States
  2. 2. Department of Endodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Periodontics and Dental Hygiene, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX, United States
  4. 4. Dental Students’ Research Committee, Department of Pediatricts, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Dental Students’ Research Committee, Department of Prosthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Endodontic Journal Published:2019


Abstract

Introduction: Phentolamine mesylate (OraVerse) is mostly used to reverse soft tissue anesthesia after dental procedures. The aim of the present study was to evaluate the effect of the injection of Ora Verse on postoperative pain after root canal treatment in patients with symptomatic irreversible pulpitis. Methods and Materials: In this randomized single-blind clinical trial study, 100 patients (50 per group) with symptomatic irreversible pulpitis in the first or second mandibular molars, randomly received either Ora Verse or sham treatment after a single-visit root canal therapy. Each patient recorded their pain score, using a Heft Parker visual analogue scale, before and after 6, 12, 24, 36, 48, and 72 h of the treatment. They also monitored their soft-tissue anesthesia every 15 min for 5 h. Data were analyzed by t-test and repeated measured ANOVA statistical tests. The level of significance was set at 0.05. Results: Patients who received phentolamine had significantly higher pain scores at 6- and 12-h postoperative intervals compared with those receiving sham treatment (P=0.01 and P=0.00 respectively). Consumption of analgesics in Ora Verse group was significantly higher than that of the sham group (P=0.48). Conclusion: Although phentolamine accelerated the reversal of normal soft tissue sensation after the dental visit, it increased postoperative pain in patients suffering from symptomatic irreversible pulpitis, which may limit phentolamine administration in this group. © The Authors. 2018.
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