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Nanobodies, the Potent Agents to Detect and Treat the Coronavirus Infections: A Systematic Review Publisher Pubmed



Zare H1 ; Aghamollaei H2 ; Hosseindokht M3 ; Heiat M4 ; Razei A5 ; Bakherad H6
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
  2. 2. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Department of Molecular Medicine, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  4. 4. Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Science, Tehran, Iran
  6. 6. Department of Pharmaceutical Biotechnology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Molecular and Cellular Probes Published:2021


Abstract

The newly emerged coronavirus (SARS-CoV-2) continues to infect humans, and no effective treatment has yet been found. Antibody therapy is one way to control infection caused by COVID-19. However, the use of classical antibodies raises complex issues. Heavy chain antibodies (HCAbs) are single-domain antibodies derived from the Camelidae family. The variable part of these antibodies (Nanobodies or VHH) has interesting properties such as small size, cost-effective production, and good tissue permeability, causing VHH to be regarded as an antiviral therapeutics. However, the small size of nanobodies may lead to low antigen binding affinity and rapid renal clearance. In this systematic review, the application of nanobodies in the treatment of COVID-19 infection and other similar infections (MERS and SARS) was reviewed. © 2020
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