Tehran University of Medical Sciences

Science Communicator Platform

Faculty Members have conducted research related to the Diphenylpiperazine Attached to Different Triazole Acetamide Derivatives As a Potent Α-Glucosidase Inhibitor, New Insight Into the in Silico Study of an Uncompetitive Inhibitor
Seyed Esmaeil Sadat Ebrahimi
Seyed Esmaeil Sadat Ebrahimi

Professor of Pharmaceutical Chemistry

Department Medicinal Chemistry

School of Pharmacy

Drug Design and Development Research Center

Tehran University of Medical Sciences

All Documents
1. Exploring Novel Nitrofuryl-1,3,4-Thiadiazole-Based Derivatives: Design, Synthesis, and Evaluation of in Vitro Leishmanicidal and Trypanocidal Activity, Archiv der Pharmazie (2026)
2. Potent and Selective Α-Glucosidase Inhibition by Coumarin–Triazole Conjugates: Design, in Vivo Evaluation, and Computational Insights, RSC Advances (2026)
3. Identification of Novel Triazolopyrimidines As Potent Α-Glucosidase Inhibitor Through Design, Synthesis, Biological Evaluations, and Computational Analysis, Scientific Reports (2025)
4. Identification of Novel Triazolopyrimidines As Potent Α-Glucosidase Inhibitor Through Design, Synthesis, Biological Evaluations, and Computational Analysis, Scientific Reports (2025)
5. Development of Novel Radiolabeled Antibody-Conjugated Graphene Quantum Dots for Targeted in Vivo Breast Cancer Imaging and Biodistribution Studies, Arabian Journal of Chemistry (2024)
6. Identification of Furo[2,3-D]Pyrimidin-4-Ylsulfanyl-1,3,4-Thiadiazole Derivatives As Novel Flt3-Itd Inhibitors, European Journal of Medicinal Chemistry (2024)
7. Synthesis, Molecular Docking, and Biological Evaluation of Pyridin-3-Yl-Pyrimidin-2-Yl-Triazole Derivatives As Anti-Cancer Agents, Polycyclic Aromatic Compounds (2024)
8. Imidazo[1,2-C]Quinazolines As a Novel and Potent Scaffold of Α-Glucosidase Inhibitors: Design, Synthesis, Biological Evaluations, and in Silico Studies, Scientific Reports (2023)
9. Synthesis and Tyrosinase Inhibitory Activities of Novel Isopropylquinazolinones, BMC Chemistry (2023)
10. Synthesis, in Vitro Inhibitor Screening, Structure–Activity Relationship, and Molecular Dynamic Simulation Studies of Novel Thioquinoline Derivatives As Potent Α-Glucosidase Inhibitors, Scientific Reports (2023)
11. Synthesis, Α-Glucosidase Inhibitory Activity and Docking Studies of Novel Ethyl 1,2,3-Triazol-4-Ylmethylthio-5,6-Diphenylpyridazine-4-Carboxylate Derivatives, BMC Chemistry (2023)
12. 18F-Fdg Micropet and Mri Targeting Breast Cancer Mouse Model With Designed Synthesis Nanoparticles, Journal of Nanomaterials (2022)
13. Novel Phenylurea-Pyridinium Derivatives As Potent Urease Inhibitors: Synthesis, in Vitro, and in Silico Studies, Journal of Molecular Structure (2022)
14. Synthesis and Bioactivities Evaluation of Quinazolin-4(3H)-One Derivatives As Α-Glucosidase Inhibitors, BMC Chemistry (2022)
15. Chlorambucil-Chitosan Nano-Conjugate: An Efficient Agent Against Breast Cancer Targeted Therapy, Current Drug Delivery (2021)
16. Chromone Derivatives Bearing Pyridinium Moiety As Multi-Target-Directed Ligands Against Alzheimer's Disease, Bioorganic Chemistry (2021)
17. Novel (Thio)Barbituric-Phenoxy-N-Phenylacetamide Derivatives As Potent Urease Inhibitors: Synthesis, in Vitro Urease Inhibition, and in Silico Evaluations, Structural Chemistry (2021)
18. Syntehsis and Evaluation of Gd3+ -Trp-Plga As Novel Nanosized Mr Tumor Imaging Candidate, Nanomedicine Journal (2021)
19. Correction To: The Efficacy of Etanercept As Anti-Breast Cancer Treatment Is Attenuated by Residing Macrophages (Bmc Cancer, (2020), 20, 1, (836), 10.1186/S12885-020-07228-Y), BMC Cancer (2020)
20. Design and Synthesis of Novel Pyridazine N-Aryl Acetamides: In-Vitro Evaluation of Α-Glucosidase Inhibition, Docking, and Kinetic Studies, Bioorganic Chemistry (2020)
21. Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives, Journal of Heterocyclic Chemistry (2020)
22. Efficient One-Pot Synthesis of Novel 6′,9′-Dihydro-2H,7′H-Spiro[Pyrimidine-5,8′-[1,3]Dioxolo[4,5-F]Quinoline]-2,4,6(1H,3H)-Trione Derivatives Under Mild and “Green” Reaction Conditions, Journal of Heterocyclic Chemistry (2020)
23. N-Acetylcysteine-Plga Nano-Conjugate: Effects on Cellular Toxicity and Uptake of Gadopentate Dimeglumine, IET Nanobiotechnology (2020)
24. New Phthalimide-Benzamide-1,2,3-Triazole Hybrids; Design, Synthesis, Α-Glucosidase Inhibition Assay, and Docking Study, Medicinal Chemistry Research (2020)
25. Novel Radiopharmaceutical (Technetium-99M)-(Dota-Nhs-Ester)-Methionine As a Spect-Ct Tumor Imaging Agent, European Journal of Pharmaceutical Sciences (2020)
26. Polyvinyl Alcohol-Graphene Oxide Nanocomposites: Evaluation of Flame-Retardancy, Thermal and Mechanical Properties, Journal of Macromolecular Science# Part A: Pure and Applied Chemistry (2020)
27. The Efficacy of Etanercept As Anti-Breast Cancer Treatment Is Attenuated by Residing Macrophages, BMC Cancer (2020)
28. 3-Aryl Coumarin Derivatives Bearing Aminoalkoxy Moiety As Multi-Target-Directed Ligands Against Alzheimer's Disease, Chemistry and Biodiversity (2019)
29. Antioxidant Activity and Phytochemical Screening of Ficus Benghalensis Aerial Roots Fractions, Journal of Reports in Pharmaceutical Sciences (2019)
30. Cholinesterase Inhibition Activity and Docking Simulation Study of Coumarin Mannich Base Derivatives, Journal of Sciences# Islamic Republic of Iran (2019)
31. Investigation of Reducing Omniscan Toxicity Using Intracellular and Targeted N-Acetylcysteine Lysine Complex, Letters in Drug Design and Discovery (2019)
32. New 99M Tc(Co) 3 -Radiolabeled Arylpiperazine Pharmacophore As Potent 5Ht 1A Serotonin Receptor Radiotracer: Docking Studies, Chemical Synthesis, Radiolabeling, and Biological Evaluation, Journal of Labelled Compounds and Radiopharmaceuticals (2019)
33. Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major, Iranian Journal of Pharmaceutical Research (2019)
34. Glutathione Conjugated Polyethylenimine on the Surface of Fe 3 O 4 Magnetic Nanoparticles As a Theranostic Agent for Targeted and Controlled Curcumin Delivery, Journal of Biomaterials Science# Polymer Edition (2018)
35. An Efficient, Four-Component Reaction for the Synthesis of Novel Carbamodithioates, Journal of Sulfur Chemistry (2017)
36. Coumarin Derivatives Bearing Benzoheterocycle Moiety: Synthesis, Cholinesterase Inhibitory, and Docking Simulation Study, Iranian Journal of Basic Medical Sciences (2017)
37. Cu(Ii)-Β-Cyclodextrin-Catalyzed Synthesis of Spiro[Indoline-3,4′-Pyrano[3,2-C]Chromene]-3′-Carbonitrile Derivatives, Synthetic Communications (2017)
38. Gd3+-Asparagine-Anionic Linear Globular Dendrimer Second-Generation G2 Complexes: Novel Nanobiohybrid Theranostics, Contrast Media and Molecular Imaging (2017)
39. Hetero-Annulated Coumarins As New Ache/Buche Inhibitors: Synthesis and Biological Evaluation, Medicinal Chemistry Research (2016)
40. Novel Chlorambucil-Conjugated Anionic Linear-Globular Peg-Based Second-Generation Dendrimer: In Vitro/In Vivo Improved Anticancer Activity, OncoTargets and Therapy (2016)
41. Synthesis and Cytotoxicity of Novel Chromenone Derivatives Bearing 4-Nitrophenoxy Phenyl Acryloyl Moiety, Journal of the Iranian Chemical Society (2016)
42. Three-Component One-Pot Synthesis of Dihydrochromeno[4,3-B]Pyrazolo[4,3-E]Pyridines, Heterocyclic Communications (2016)
43. A Highly Efficient Method for the Synthesis of Novel 1'H-Spiro[Indene-2,2'-Quinazoline]-1,3,4'(3'H)-Trione Derivatives, Journal of Chemical Research (2015)
44. Effects of Polyethyleneimine-Functionalized Mcm-41 on Flame Retardancy and Thermal Stability of Polyvinyl Alcohol, Particuology (2015)
45. Mycochemical Investigation of the Turkey Tail Medicinal Mushroom Trametes Versicolor (Higher Basidiomycetes): A Potential Application of the Isolated Compounds in Documented Pharmacological Studies, International Journal of Medicinal Mushrooms (2015)
46. New Pla/Pei-Functionalized Fe3o4 Nanocomposite: Preparation and Characterization, Journal of Industrial and Engineering Chemistry (2015)
47. Polyethyleneimine-Modified Superparamagnetic Fe3o4 Nanoparticles: An Efficient, Reusable and Water Tolerance Nanocatalyst, Journal of Magnetism and Magnetic Materials (2015)
48. Straightforward Approach Toward Dihydrothiazoles Via Intramolecular Bromocyclization, Synthetic Communications (2015)
49. Synthesis and Evaluation of Chroman-4-One Linked to N-Benzyl Pyridinium Derivatives As New Acetylcholinesterase Inhibitors, Archiv der Pharmazie (2015)
50. Direct Labelling of Octreotide With 99Mtc: Effect of Different Concentration of Reducing Agents and Amount of Sodium Pertechnetate on Radiolabelling Efficiency, Applied Radiation and Isotopes (2003)