Tehran University of Medical Sciences

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Faculty Members have conducted research related to the The Role of Dna Methylation in Progression of Neurological Disorders and Neurodegenerative Diseases As Well As the Prospect of Using Dna Methylation Inhibitors As Therapeutic Agents for Such Disorders
Mahmoud Ghazi Khansari
Mahmoud Ghazi Khansari

Professor of Pharmacology and Toxicology

Department Pharmacology

School of Medicine

Tehran University of Medical Sciences

All Documents
1. Editorial Expression of Concern: The Aqueous Extract of Artemisia Absinthium L. Stimulates Ho-1/Mt-1/Cyp450 Signaling Pathway Via Oxidative Stress Regulation Induced by Aluminium Oxide Nanoparticles (Α and Γ) Animal Model, BMC Complementary Medicine and Therapies (2025)
2. Bisphenol a in Dairy Products, Amount, Potential Risks, and the Various Analytical Methods, a Systematic Review, Food Chemistry: X (2024)
3. Common and Novel Methods for the Identification of Bisphenol a in Tea Samples: A Systematic Review Study, Microchemical Journal (2024)
4. Protective Effects of Glatiramer Acetate Against Paclitaxel-Induced Peripheral Neuropathy in Rats: A Role for Inflammatory Cytokines and Oxidative Stress, Neurochemical Research (2024)
5. Self-Assembled Nipam–Peg–Nipam Polymeric Nanomicelles for the Delivery of Zinc Protoporphyrin: A Potential Stimuli-Triggered Cancer Treatment Approach, Journal of Materials Science (2024)
6. The Bioassay Tests and Mass Spectrometry for Evaluation of Xenoestrogens in Tuna Fish, Applied Food Research (2024)
7. Antimicrobial Activity of Zeolite/Zinc Oxide Nanocomposite Containing Aloe Vera Gel Against Shigella Spp. and Its Durability Effects on Strawberries, BioNanoScience (2023)
8. Association Between Non-Alcoholic Fatty Liver Disease and Heavy Metal Exposure: A Systematic Review, Biological Trace Element Research (2023)
9. Development and Validation of a Multi-Residue Method for Determination of Antimicrobial Sulfonamides, Macrolides and Quinolones in Iranian Feta Cheese by Spe Clean-Up and Lc-Ms/Ms, International Dairy Journal (2023)
10. Evaluation of Zinc Oxide Nanocomposite With Aloe Vera Gel for Packaging of Chicken Fillet Against Salmonella Typhi and Salmonella Para Typhi A, Food Science and Nutrition (2023)
11. Method Validation for Simultaneous Determination of Macrolides, Quinolones, and Sulfonamides Antibiotics in Iranian Yogurt Samples by Spe Clean-Up and Uhplc-Ms/Ms, Microchemical Journal (2023)
12. The Aqueous Extract of Artemisia Absinthium L. Stimulates Ho-1/Mt-1/Cyp450 Signaling Pathway Via Oxidative Stress Regulation Induced by Aluminium Oxide Nanoparticles (Α and Γ) Animal Model, BMC Complementary Medicine and Therapies (2023)
13. Antibiotic Treatment During Pregnancy and Lactation in Dams Exacerbates Clinical Symptoms and Inflammatory Responses in Offspring With Experimental Autoimmune Encephalomyelitis, Journal of Neuroimmunology (2022)
14. Cardioprotective Effects of Sodium Thiosulfate Against Doxorubicin-Induced Cardiotoxicity in Male Rats, BMC Pharmacology and Toxicology (2022)
15. Deep Eutectic Solvent As the Acceptor Phase in Three-Phase Hollow Fiber Liquid-Phase Microextraction for the Determination of Pyrethroid Insecticides From Environmental Water Samples Prior to Hplc, Biomedical Chromatography (2022)
16. Diagnostic Biomarkers of Heat Stress Induced- Dna in Occupational Exposure: A Systematic Review, Journal of Health and Safety at Work (2022)
17. Effect of Heat Stress on Dna Damage: A Systematic Literature Review, International Journal of Biometeorology (2022)
18. Evaluation of Dna Methylation in Bdnf, Slc6a4, Nr3c1 and Fkbp5 Before and After Treatment With Selective Serotonin-Reuptake Inhibitor in Major Depressive Disorder, Epigenomics (2022)
19. Evaluation of Statins As a New Therapy to Alleviate Chronotropic Dysfunction in Cirrhotic Rats, Life Sciences (2022)
20. Investigating the Protective Effects of Aqueous Extract of the Wormwood Plant (Artemisia Absinthium) on Alumina Nanoparticle-Induced Pulmonary Toxicity in Male Wistar Rats, Journal of Health and Safety at Work (2022)
21. Melatonin Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis by Modulating the Kynurenine Pathway, Scientific Reports (2022)
22. Montelukast Suppresses the Development of Irritable Bowel Syndrome Phenotype Possibly Through Modulating Nf-Κb Signaling in an Experimental Model, Inflammopharmacology (2022)
23. Neuroprotective Effect of Sumatriptan in Pentylenetetrazole-Induced Seizure Is Mediated Through N-Methyl-D-Aspartate/Nitric Oxide and Camp Response Element-Binding Protein Signaling Pathway, Fundamental and Clinical Pharmacology (2022)
24. Reducing the Risk of Death Induced by Aluminum Phosphide Poisoning: The New Therapies, Chemosphere (2022)
25. Sensing of Oxidative Stress Biomarkers: The Cardioprotective Effect of Taurine & Grape Seed Extract Against the Poisoning Induced by an Agricultural Pesticide Aluminum Phosphide, Chemosphere (2022)
26. Thermal Stress and Tio2 Nanoparticle–Induced Oxidative Dna Damage and Apoptosis in Mouse Hippocampus, Environmental Science and Pollution Research (2022)
27. Toxicity of Hydrogen Sulfide on Rat Brain Neurons, Drug Research (2022)
28. Design and Synthesis of Tetrahydropyrimidinone(Thione)-Triazole Hybrid Scaffolds and Evaluation of Their Biological Activities, Phosphorus# Sulfur and Silicon and the Related Elements (2021)
29. Foretinib Induces G2/M Cell Cycle Arrest, Apoptosis, and Invasion in Human Glioblastoma Cells Through C-Met Inhibition, Cancer Chemotherapy and Pharmacology (2021)
30. Glatiramer Acetate Attenuates Depressive/Anxiety-Like Behaviors and Cognitive Deficits Induced by Post-Weaning Social Isolation in Male Mice, Psychopharmacology (2021)
31. Investigation of Geological and Environmental Factors of Airborne Suspended Particles From Sand and Gravel Quarries in the West of Tehran, Iran, Journal of Health and Safety at Work (2021)
32. Method Development for Determination of Imatinib and Its Major Metabolite, N-Desmethyl Imatinib, in Biological and Environmental Samples by Sa–Shs–Lpme and Hplc, Biomedical Chromatography (2021)
33. Study of the Cardioprotective Effects of Crocin on Human Cardiac Myocyte Cells and Reduction of Oxidative Stress Produced by Aluminum Phosphide Poisoning, Journal of Pharmacy and Pharmacology (2021)
34. Assessment of Tramadol Pharmacokinetics in Correlation With Cyp2d6 and Clinical Symptoms, Drug Metabolism and Personalized Therapy (2020)
35. Identification of Catecholamine Neurotransmitters Using a Fluorescent Electronic Tongue, ACS Chemical Neuroscience (2020)
36. Involvement of Nnos, and Α1, Α2, Β1, and Β2 Subunits of Soluble Guanylyl Cyclase Genes Expression in Anticonvulsant Effect of Sumatriptan on Pentylenetetrazole-Induced Seizure in Mice, Iranian Journal of Pharmaceutical Research (2020)
37. Protective Effects of Gold Nanoparticles Against Malathion-Induced Cytotoxicity in Caco-2 Cells, Acta Medica Iranica (2020)
38. Combination Therapy of Mesenchymal Stromal Cells and Sulfasalazine Attenuates Trinitrobenzene Sulfonic Acid Induced Colitis in the Rat: The S1p Pathway, Journal of Cellular Physiology (2019)
39. Enhancing Analgesic and Anti-Inflammatory Effects of Capsaicin When Loaded Into Olive Oil Nanoemulsion: An in Vivo Study, International Journal of Pharmaceutics (2019)
40. Introducing a New Standardized Nanomaterial Environmental Toxicity Screening Testing Procedure, Iso/Ts 20787: Aquatic Toxicity Assessment of Manufactured Nanomaterials in Saltwater Lakes Using Artemia Sp. Nauplii, Toxicology Mechanisms and Methods (2019)
41. Pharmacokinetic Changes of Tramadol in Rats With Hepatotoxicity Induced by Ethanol and Acetaminophen in Perfused Rat Liver Model, Alcohol (2019)
42. Protective Effect of Salvia Officinalis Extract on Deltamethrin-Induced Hepatotoxicity in Rats, Journal of Mazandaran University of Medical Sciences (2019)
43. Thymol Reduces Acetic Acid-Induced Inflammatory Response Through Inhibition of Nf-Kb Signaling Pathway in Rat Colon Tissue, Inflammopharmacology (2019)
44. Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions, Iranian Journal of Parasitology (2018)
45. Correlation Between Plasma Concentrations of Tramadol and Its Metabolites and the Incidence of Seizure in Tramadol-Intoxicated Patients, Drug Metabolism and Personalized Therapy (2018)
46. Effect of Metformin on Germ Cell-Specific Apoptosis, Oxidative Stress and Epididymal Sperm Quality After Testicular Torsion/Detorsion in Rats, Andrologia (2018)
47. Maternal Dietary Nitrate Intake and Risk of Neural Tube Defects: A Systematic Review and Dose-Response Meta-Analysis, Food and Chemical Toxicology (2018)
48. Maternal Exposure to Silver Nanoparticles Are Associated With Behavioral Abnormalities in Adulthood: Role of Mitochondria and Innate Immunity in Developmental Toxicity, NeuroToxicology (2018)
49. Pirfenidone Protects Against Paraquat-Induced Lung Injury and Fibrosis in Mice by Modulation of Inflammation, Oxidative Stress, and Gene Expression, Food and Chemical Toxicology (2018)
50. Radioprotective Effect of Melatonin on Expression of Cdkn1a and Rad50 Genes in Rat Peripheral Blood, Journal of Cancer Research and Therapeutics (2018)
51. Sildenafil Protective Effects on High Glucose-Induced Neurotoxicity in Pc12 Cells: The Role of Oxidative Stress, Apoptosis, and Inflammation Pathways in an in Vitro Cellular Model for Diabetic Neuropathy, Neurological Research (2018)
52. Synergistic Effect of Rapamycin and Metformin Against Germ Cell Apoptosis and Oxidative Stress After Testicular Torsion/Detorsion-Induced Ischemia/Reperfusion in Rats, Biomedicine and Pharmacotherapy (2018)
53. Ultrasound-Assisted Switchable Solvent in Determination of Quaternary Ammonium Herbicide Paraquat in Biological, Environmental Water, and Apple Juice Samples Using Chemical Reduction Process Coupled to Gc–Ms Detection, Chromatographia (2018)
54. A Disposition Kinetic Study of Tramadol in Bile Duct Ligated Rats in Perfused Rat Liver Model, Biomedicine and Pharmacotherapy (2017)
55. Anti-Tumour Activity of Tivozanib, a Pan-Inhibitor of Vegf Receptors, in Therapy-Resistant Ovarian Carcinoma Cells, Scientific Reports (2017)
56. Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells, Scientific Reports (2017)
57. Colorimetric Fingerprints of Gold Nanorods for Discriminating Catecholamine Neurotransmitters in Urine Samples, Scientific Reports (2017)
58. Effect of Crude Venom of Odonthobuthus Doriae Scorpion in Cell Culture Using Ion Channel Modulators, Iranian Journal of Pharmaceutical Research (2017)
59. Improvement of Memory and Learning by Intracerebroventricular Microinjection of T3 in Rat Model of Ischemic Brain Stroke Mediated by Upregulation of Bdnf and Gdnf in Ca1 Hippocampal Region, DARU# Journal of Pharmaceutical Sciences (2017)
60. In-Vitro Cytotoxicity and Combination Effects of the Docetaxel-Conjugated and Doxorubicin-Conjugated Poly(Lactic Acid)-Poly(Ethylene Glycol)-Folate-Based Polymeric Micelles in Human Ovarian Cancer Cells, Journal of Pharmacy and Pharmacology (2017)
61. Ion-Pair Switchable-Hydrophilicity Solvent-Based Homogeneous Liquid–Liquid Microextraction for the Determination of Paraquat in Environmental and Biological Samples Before High-Performance Liquid Chromatography, Journal of Separation Science (2017)
62. N-Acetylcysteine-Loaded Plga Nanoparticles Outperform Conventional N-Acetylcysteine in Acute Lung Injuries in Vivo, International Journal of Polymeric Materials and Polymeric Biomaterials (2017)
63. Nortriptyline Protects Testes Against Germ Cell Apoptosis and Oxidative Stress Induced by Testicular Ischaemia/Reperfusion, Andrologia (2017)
64. Protective Effects of Gabapentin Against the Seizure Susceptibility and Comorbid Behavioral Abnormalities in the Early Socially Isolated Mice, European Journal of Pharmacology (2017)
65. Rapamycin Protects Testes Against Germ Cell Apoptosis and Oxidative Stress Induced by Testicular Ischemia-Reperfusion, Iranian Journal of Basic Medical Sciences (2017)
66. Role of Tnf-Α in Aflatoxin B-1 Induced Hepatic Toxicity in Isolated Perfused Rat Liver Model, Acta Medica Iranica (2017)
67. Streptozotocin Induced Oxidative Stress, Innate Immune System Responses and Behavioral Abnormalities in Male Mice, Neuroscience (2017)
68. Ultrasonic Assisted Switchable Solvent Based on Liquid Phase Microextraction Combined With Micro Sample Injection Flame Atomic Absorption Spectrometry for Determination of Some Heavy Metals in Water, Urine and Tea Infusion Samples, Journal of Molecular Liquids (2017)
69. Biocatalytic Conversion and Detoxification of Imipramine by the Laccase-Mediated System, International Biodeterioration and Biodegradation (2016)
70. Laccase-Catalyzed Treatment of Ketoconazole, Identification of Biotransformed Metabolites, Determination of Kinetic Parameters, and Evaluation of Micro-Toxicity, Journal of Molecular Catalysis B: Enzymatic (2016)
71. Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice, Brain Research Bulletin (2016)
72. Nmda Receptors Are Involved in the Antidepressant-Like Effects of Capsaicin Following Amphetamine Withdrawal in Male Mice, Neuroscience (2016)
73. A Semipolar Fraction of Petroleum Ether Extract of Artemisia Aucheri Induces Apoptosis and Enhances the Apoptotic Response to Doxorubicin in Human Neuroblastoma Sknmc Cell Line, Research in Pharmaceutical Sciences (2015)
74. Cytotoxic Effect of Iranian Vipera Lebetina Snake Venom on Huvec Cells, Iranian Journal of Pharmaceutical Research (2015)
75. Deferoxamine Preconditioning to Restore Impaired Hif-1Α-Mediated Angiogenic Mechanisms in Adipose-Derived Stem Cells From Stz-Induced Type 1 Diabetic Rats, Cell Proliferation (2015)
76. Development and Optimization of N-Acetylcysteine-Loaded Poly (Lactic-Co-Glycolic Acid) Nanoparticles by Electrospray, International Journal of Biological Macromolecules (2015)