Tehran University of Medical Sciences

Science Communicator Platform

Faculty Members have conducted research related to the Discovery of Direct Inhibitor of Kras Oncogenic Protein by Natural Products: A Combination of Pharmacophore Search, Molecular Docking, and Molecular Dynamic Studies
Maliheh Barazandeh Tehrani
Maliheh Barazandeh Tehrani

Associate Professor of Pharmaceutical Chemistry

Department Medicinal Chemistry

School of Pharmacy

Tehran University of Medical Sciences

All Documents
1. Exploring Novel Nitrofuryl-1,3,4-Thiadiazole-Based Derivatives: Design, Synthesis, and Evaluation of in Vitro Leishmanicidal and Trypanocidal Activity, Archiv der Pharmazie (2026)
2. Identification of Novel Triazolopyrimidines As Potent Α-Glucosidase Inhibitor Through Design, Synthesis, Biological Evaluations, and Computational Analysis, Scientific Reports (2025)
3. Identification of Novel Triazolopyrimidines As Potent Α-Glucosidase Inhibitor Through Design, Synthesis, Biological Evaluations, and Computational Analysis, Scientific Reports (2025)
4. New Coumarin–Chalcone–Triazole Hybrids As Promising Anti-Diabetic Agents: From Molecular Design to in Vivo Validation, RSC Advances (2025)
5. New Coumarin–Chalcone–Triazole Hybrids As Promising Anti-Diabetic Agents: From Molecular Design to in Vivo Validation, RSC Advances (2025)
6. Design, Synthesis, and Evaluation of Novel Substituted Imidazo[1,2-C]Quinazoline Derivatives As Potential Α-Glucosidase Inhibitors With Bioactivity and Molecular Docking Insights, Scientific Reports (2024)
7. Structure-Based Drug Design of New Cinnamic Acid Derivatives As Tyrosinase Inhibitors, Letters in Organic Chemistry (2024)
8. Dual Functional Cholinesterase and Carbonic Anhydrase Inhibitors for the Treatment of Alzheimer's Disease: Design, Synthesis, in Vitro, and in Silico Evaluations of Coumarin-Dihydropyridine Derivatives, Journal of Molecular Structure (2023)
9. Evaluation of Inhibitory Effect and Docking Study of Triazolyl Chromanone Oxime Ether Derivatives on Aromatase Enzyme Effective in Breast Cancer, Journal of Mazandaran University of Medical Sciences (2023)
10. Imidazo[1,2-C]Quinazolines As a Novel and Potent Scaffold of Α-Glucosidase Inhibitors: Design, Synthesis, Biological Evaluations, and in Silico Studies, Scientific Reports (2023)
11. Novel Fluoroquinolones Analogues Bearing 4-(Arylcarbamoyl)Benzyl: Design, Synthesis, and Antibacterial Evaluation, Molecular Diversity (2023)
12. Ugi Bis-Amide Derivatives As Tyrosinase Inhibitor; Synthesis, Biology Assessment, and in Silico Analysis, Chemistry and Biodiversity (2023)
13. Design and Synthesis of Novel Nitrothiazolacetamide Conjugated to Different Thioquinazolinone Derivatives As Anti-Urease Agents, Scientific Reports (2022)
14. Design, Synthesis, and in Silico Studies of Benzimidazole Bearing Phenoxyacetamide Derivatives As Α-Glucosidase and Α-Amylase Inhibitors, Journal of Molecular Structure (2022)
15. 4-Oxobenzo[D]1,2,3-Triazin-Pyridinium-Phenylacetamide Derivatives As New Anti-Alzheimer Agents: Design, Synthesis, in Vitro Evaluation, Molecular Modeling, and Molecular Dynamic Study, Structural Chemistry (2020)
16. Multicomponent Reaction of Amine, Carbon Disulfide, and Fluoronitrobenzene Via Nucleophilic Attack on the Fluorinated Carbon for the Synthesis of Nitrophenyl Methylcarbamodithioates, Journal of the Chinese Chemical Society (2020)
17. Spectrophotometric Methods for Determination of Sunitinib in Pharmaceutical Dosage Forms Based on Ion-Pair Complex Formation, Iranian Journal of Pharmaceutical Research (2020)
18. Design, Synthesis, and Biological Evaluation of Novel 4-Oxobenzo[D]1,2,3-Triazin-Benzylpyridinum Derivatives As Potent Anti-Alzheimer Agents, Bioorganic and Medicinal Chemistry (2019)
19. Design, Synthesis, and Cholinesterase Inhibition Assay of Coumarin-3-Carboxamide-N-Morpholine Hybrids As New Anti-Alzheimer Agents, Chemistry and Biodiversity (2019)
20. Design, Synthesis, in Vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-A]Pyridines As Potent Anti-Breast Cancer Agents, Anti-Cancer Agents in Medicinal Chemistry (2019)
21. Phthalimide-1,2,3-Triazole Hybrid Compounds As Tyrosinase Inhibitors; Synthesis, Biological Evaluation and Molecular Docking Analysis, Journal of Molecular Structure (2019)
22. Spectrofluorimetric Method for Determination of Bupropion in Pharmaceutical Dosage Forms; [Methode De Determination Spectrofluorimetrique Du Bupropion Dans Les Formulations Pharmaceutiques], Annales Pharmaceutiques Francaises (2019)
23. Spectrophotometric Determination of Fingolimod in Pharmaceutical Dosage Forms, Asian Journal of Chemistry (2019)
24. The Role of Pramipexole Functionalized Mwcnts to the Fabrication of Pd Nanoparticles Modified Gce for Electrochemical Detection of Dopamine, DARU# Journal of Pharmaceutical Sciences (2019)
25. Evaluating the Accumulation Trend of L-Dopa in Dark-Germinated Seeds and Suspension Cultures of Phaseolus Vulgaris L. by an Efficient Uv-Spectrophotometric Method, Quimica Nova (2018)
26. Novel Quinazolin-4(3H)-One Linked to 1,2,3-Triazoles: Synthesis and Anticancer Activity, Chemical Biology and Drug Design (2018)
27. Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green As Chromogenic Reagent, Asian Journal of Chemistry (2018)
28. Synthesis of 6-(Phenanthrene-3-Yl)-2,3-Dihydro-1,2,4,-Triazine-3-Thione As a New Reagent for the Non-Extractive Spectrophotometric Determination of Cu(Ii), Iranian Journal of Chemistry and Chemical Engineering (2018)
29. 1,2,3-Triazole-Isoxazole Based Acetylcholinesterase Inhibitors: Synthesis, Biological Evaluation and Docking Study, Letters in Drug Design and Discovery (2017)
30. Diagnosing Mucopolysaccharidosis Type Iv a by the Fluorometric Assay of N-Acetylgalactosamine-6-Sulfate Sulfatase Activity, Journal of Diabetes and Metabolic Disorders (2017)
31. Validated Spectrophtometric Method for Simultaneous Determination of Buprenorphine and Naloxone in Pharmaceutical Dosage Forms, Iranian Journal of Pharmaceutical Research (2017)
32. A Novel Way for Detection of Antiparkinsonism Drug Entacapone Via Electrodeposition of Silver Nanoparticles/Functionalized Multi-Walled Carbon Nanotubes As an Amperometric Sensor, Materials Science and Engineering C (2016)
33. Design and Synthesis of Novel Anti-Alzheimer's Agents: Acridine-Chromenone and Quinoline-Chromenone Hybrids, Bioorganic Chemistry (2016)
34. Fourth-Order Derivative Spectrophotometric Method for Simultaneous Determination of Pseudoephedrine and Naproxen in Pharmaceutical Dosage Forms, Research in Pharmaceutical Sciences (2016)
35. Spectrophotometric and Spectrofluorimetric Methods for the Determination of Ropinirole Content in Pharmaceutical Dosage Forms, Journal of Chinese Pharmaceutical Sciences (2016)
36. Spectrophotometric Determination of Trace Co (Ii) With Naphthylglyoxalaldoxime As a Newly Synthesized Reagent, Research Journal of Pharmaceutical# Biological and Chemical Sciences (2016)
37. A Stability Indicating Hplc Method for the Determination of Fluvoxamine in Pharmaceutical Dosage Forms, Iranian Journal of Pharmaceutical Research (2015)
38. Development and Validation of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Ibuprofen and Caffeine, Journal of Analytical Chemistry (2015)