Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Evaluation of the Anti-Tumor Effects of an Anti-Human Epidermal Growth Factor Receptor 2 (Her2) Monoclonal Antibody in Combination With Cd11b+/Gr-1+ Myeloid Cells Depletion Using a Recombinant Peptibody in 4 T1-Her2 Tumor Model
Fazel Shokri
Fazel Shokri

Professor of Medical Immunology

Department Pathobiology

School of Public Health

Tehran University of Medical Sciences

Related Documents
1. Evaluation of the Anti-Tumor Effects of an Anti-Human Epidermal Growth Factor Receptor 2 (Her2) Monoclonal Antibody in Combination With Cd11b+/Gr-1+ Myeloid Cells Depletion Using a Recombinant Peptibody in 4 T1-Her2 Tumor Model, International Immunopharmacology (2023)
2. Cloning, Expression and Characterization of a Peptibody to Deplete Myeloid Derived Suppressor Cells in a Murine Mammary Carcinoma Model, Protein Expression and Purification (2022)
3. Myeloid-Derived Suppressor Cells (Mdscs) Depletion by Cabozantinib Improves the Efficacy of Anti-Her2 Antibody-Based Immunotherapy in a 4T1-Her2 Murine Breast Cancer Model, International Immunopharmacology (2022)
4. Epitope Mapping of Human Her2 Specific Mouse Monoclonal Antibodies Using Recombinant Extracellular Subdomains, Asian Pacific Journal of Cancer Prevention (2017)
5. Polyclonal Antibody Against Different Extracellular Subdomains of Her2 Induces Tumor Growth Inhibition in Vitro, Iranian Journal of Immunology (2017)
6. Differential Effects of Inhibitory and Stimulatory Anti-Her2 Monoclonal Antibodies on Akt/Erk Signaling Pathways, Asian Pacific Journal of Cancer Prevention (2018)
7. Antibody Response to Her2 Extracellular Domain and Subdomains in Mouse Following Dna Immunization, Tumor Biology (2016)
8. Hersintuzumab: A Novel Humanized Anti-Her2 Monoclonal Antibody Induces Potent Tumor Growth Inhibition, Investigational New Drugs (2018)
9. Immunization With Her2 Extracellular Subdomain Proteins Induces Cellular Response and Tumor Growth Inhibition in Mice, Immunotherapy (2018)
10. Potent Anti-Tumor Immune Response and Tumor Growth Inhibition Induced by Her2 Subdomain Fusion Protein in a Mouse Tumor Model, Journal of Cancer Research and Clinical Oncology (2023)
11. Differential Tumor Inhibitory Effects Induced by Her3 Extracellular Subdomain-Specific Mouse Monoclonal Antibodies, Cancer Chemotherapy and Pharmacology (2022)
12. Comparison of Different Transient Gene Expression Systems for the Production of a New Humanized Anti-Her2 Monoclonal Antibody (Hersintuzumab), DARU# Journal of Pharmaceutical Sciences (2023)
13. Potent Synergistic Anti-Tumor Activity of a Novel Humanized Anti-Her2 Antibody Hersintuzumab in Combination With Trastuzumab in Xenograft Models, Investigational New Drugs (2021)
14. A Novel Anti-Her2 Bispecific Antibody With Potent Tumor Inhibitory Effects in Vitro and in Vivo, Frontiers in Immunology (2021)
15. Development of a Novel Inhibitory Chimeric Anti-Her2 Monoclonal Antibody, Iranian Journal of Immunology (2019)
All Documents
1. Comparative Assessment of Four Virus Neutralization Assays for Detection of Sars-Cov-2 Neutralizing Antibodies, Analytical Biochemistry (2025)
2. Production and Characterization of a Panel of Anti-Mouse Placenta-Specific Protein 1 (Plac1) Monoclonal Antibodies, Analytical Biochemistry (2025)
3. Production and Characterization of Monoclonal Antibodies Against Hepatitis B E-Antigen and Their Potential Application for Development of Hbeag Detection Elisa, Biologicals (2025)
4. Production and Characterization of Pertussis Toxin Specific Monoclonal and Polyclonal Antibodies: Implication for Toxin Purification and Detection, Toxicon (2025)
5. Clinico-Pathological and Prognostic Significance of a Combination of Tumor Biomarkers in Iranian Patients With Breast Cancer, Clinical Breast Cancer (2024)
6. Comparative Immunogenicity and Neutralization Potency of Four Approved Covid-19 Vaccines in Balb/C Mice, Iranian Journal of Immunology (2024)
7. High Purity and Recovery of Native Filamentous Hemagglutinin (Fha) From Bordetella Pertussis Using Affinity Chromatography, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2024)
8. Preclinical Assessment of a Recombinant Rbd-Fc Fusion Protein As Sars-Cov-2 Candidate Vaccine, European Journal of Microbiology and Immunology (2024)
9. A Novel Fc-Engineered Anti-Her2 Bispecific Antibody With Enhanced Antitumor Activity, Journal of Immunotherapy (2023)
10. Comparison of Different Transient Gene Expression Systems for the Production of a New Humanized Anti-Her2 Monoclonal Antibody (Hersintuzumab), DARU# Journal of Pharmaceutical Sciences (2023)
11. Cross-Reactivity of Hbe Antigen-Specific Polyclonal Antibody With Hbc Antigen, Viral Immunology (2023)
12. Diagnostic Performance of a Novel Antigen-Capture Elisa for the Detection of Sars-Cov-2, Analytical Biochemistry (2023)
13. Discovery of a Novel Marker for Human Granulocytes and Tissue Macrophages: Rtl1 Revisited, Cell and Tissue Research (2023)
14. Evaluation of the Anti-Tumor Effects of an Anti-Human Epidermal Growth Factor Receptor 2 (Her2) Monoclonal Antibody in Combination With Cd11b+/Gr-1+ Myeloid Cells Depletion Using a Recombinant Peptibody in 4 T1-Her2 Tumor Model, International Immunopharmacology (2023)
15. Immune Profiling of Sars-Cov-2; What We Know and What We Don’T Know, Iranian Journal of Allergy# Asthma and Immunology (2023)
16. Novel Monoclonal Antibodies Specific for Human Ki67 and P53 Tumor Markers in Breast Cancer Tissue Samples, Iranian Journal of Immunology (2023)
17. Novel Mouse Monoclonal Antibodies Against Bordetella Pertussis Pertactin Antigen With Versatile Applications, Journal of Microbiological Methods (2023)
18. Novel Neutralizing Mouse-Human Chimeric Monoclonal Antibodies Against the Sars-Cov-2 Receptor Binding Domain, Journal of medical microbiology (2023)
19. Potent Anti-Tumor Immune Response and Tumor Growth Inhibition Induced by Her2 Subdomain Fusion Protein in a Mouse Tumor Model, Journal of Cancer Research and Clinical Oncology (2023)
20. Potential Role of Ebv and Toll-Like Receptor 9 Ligand in Patients With Systemic Lupus Erythematosus, Immunologic Research (2023)
21. Sars-Cov-2 Nucleocapsid: Biological Functions and Implication for Disease Diagnosis and Vaccine Design, Reviews in Medical Virology (2023)
22. Cloning, Expression and Characterization of a Peptibody to Deplete Myeloid Derived Suppressor Cells in a Murine Mammary Carcinoma Model, Protein Expression and Purification (2022)
23. Cross Talk Between Hepatitis B Virus and Innate Immunity of Hepatocytes, Reviews in Medical Virology (2022)
24. Differential Tumor Inhibitory Effects Induced by Her3 Extracellular Subdomain-Specific Mouse Monoclonal Antibodies, Cancer Chemotherapy and Pharmacology (2022)
25. Epitope Mapping of Neutralising Anti-Sars-Cov-2 Monoclonal Antibodies: Implications for Immunotherapy and Vaccine Design, Reviews in Medical Virology (2022)
26. Epitope Mapping of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Receptor Binding Domain-Specific Monoclonal Antibodies, Frontiers in Medicine (2022)
27. Generation and Characterization of Novel Diagnostic Mouse Monoclonal Antibodies Against Human Estrogen Receptor Alpha and Progesterone Receptor, Asian Pacific Journal of Cancer Prevention (2022)
28. Identification of Immunodominant Epitopes on Nucleocapsid and Spike Proteins of the Sars-Cov-2 in Iranian Covid-19 Patients, Pathogens and Disease (2022)
29. Immunization With Placenta-Specific 1 (Plac1) Induces Potent Anti-Tumor Responses and Prolongs Survival in a Mouse Model of Melanoma, Advances in Medical Sciences (2022)
30. Myeloid-Derived Suppressor Cells (Mdscs) Depletion by Cabozantinib Improves the Efficacy of Anti-Her2 Antibody-Based Immunotherapy in a 4T1-Her2 Murine Breast Cancer Model, International Immunopharmacology (2022)
31. Optimization of an Efficient Cell Culture Hepatitis B Infection System for Assessment of Hepatitis B Virus Neutralizing Monoclonal Antibodies, Iranian Journal of Immunology (2022)
32. Preclinical Assessment of Immunogenicity and Protectivity of Novel Ror1 Fusion Proteins in a Mouse Tumor Model, Cancers (2022)
33. A Novel Anti-Her2 Bispecific Antibody With Potent Tumor Inhibitory Effects in Vitro and in Vivo, Frontiers in Immunology (2021)
34. A Novel Tumor Inhibitory Hybridoma Monoclonal Antibody With Dual Specificity for Her3 and Her2, Current Research in Translational Medicine (2021)
35. Differential Antibody Response to Sars-Cov-2 Antigens in Recovered and Deceased Iranian Covid-19 Patients, Viral Immunology (2021)
36. Does Prior Immunization With Measles, Mumps, and Rubella Vaccines Affect the Antibody Response to Covid-19 Antigens?, Iranian Journal of Immunology (2021)
37. Endometrial Mesenchymal Stem/Stromal Cells: The Enigma to Code Messages for Generation of Functionally Active Regulatory T Cells, Stem Cell Research and Therapy (2021)
38. Illuminating the in Vitro Effects of Epstein-Barr Virus and Vitamin D on Immune Response in Multiple Sclerosis Patients, Journal of NeuroVirology (2021)
39. Influence of Pattern Recognition Receptor Ligands on Induction of Innate Immunity and Control of Hepatitis B Virus Infection, Viral Immunology (2021)
40. Menscs Exert a Supportive Role in Establishing a Pregnancy-Friendly Microenvironment by Inhibiting Th17 Polarization, Journal of Reproductive Immunology (2021)
41. Neutralization of Tetanus Toxin by a Novel Chimeric Monoclonal Antibody, Toxicon (2021)
42. Optimization of Expression and Purification of Recombinant Mouse Plac1, Avicenna Journal of Medical Biotechnology (2021)
43. Overall Status of Epstein-Barr Virus Infection, Ifn-A, and Tlr-7/9 in Patients With Systemic Lupus Erythematous, Iranian Journal of Immunology (2021)
44. Potent Synergistic Anti-Tumor Activity of a Novel Humanized Anti-Her2 Antibody Hersintuzumab in Combination With Trastuzumab in Xenograft Models, Investigational New Drugs (2021)
45. Potential Role of Viral Infection and B Cells As a Linker Between Innate and Adaptive Immune Response in Systemic Lupus Erythematosus, Immunologic Research (2021)
46. T-Cell Engager Antibodies Enable T Cells to Control Hbv Infection and to Target Hbsag-Positive Hepatoma in Mice, Journal of Hepatology (2021)
47. Contribution of Fc Fragment of Monoclonal Antibodies to Tetanus Toxin Neutralization, Neurotoxicity Research (2020)
48. Epitope Mapping of Tetanus Toxin by Monoclonal Antibodies: Implication for Immunotherapy and Vaccine Design, Neurotoxicity Research (2020)
49. Evaluation of a Novel Enzyme-Linked Immuno Assay Model to Detect E2 Antigen and Antibodies Against Core, Ns3, Ns4, and Ns5 Antigens of Hepatitis C Virus, Hepatitis Monthly (2020)
50. Immunoreactivity Pattern of Monoclonal Antibodies Against Hepatitis B Vaccine With Global Hepatitis B Virus Genotypes, Clinica Chimica Acta (2020)
51. Inhibitory Effect of Polyclonal Antibodies Against Her3 Extracellular Subdomains on Breast Cancer Cell Lines, Asian Pacific Journal of Cancer Prevention (2020)
52. Surface Modification and Bioconjugation of Anti-Cd4 Monoclonal Antibody to Magnetic Nanoparticles As a Highly Efficient Affinity Adsorbent for Positive Selection of Peripheral Blood T Cd4+ Lymphocytes, International Journal of Biological Macromolecules (2020)
53. Characterization of Monoclonal and Polyclonal Antibodies Recognizing Prostate Specific Antigen: Implication for Design of a Sandwich Elisa, Avicenna Journal of Medical Biotechnology (2019)
54. Development of a Novel Inhibitory Chimeric Anti-Her2 Monoclonal Antibody, Iranian Journal of Immunology (2019)
55. Diminished Frequency of Menstrual and Peripheral Blood Nkt-Like Cells in Patients With Unexplained Recurrent Spontaneous Abortion and Infertile Women, Reproductive Sciences (2019)
56. Effects of Influenza Derived Peptide on Cd8 T Cell Responses to Mhc Class I-Restricted Human Telomerase Reverse Transcriptase (Htert)-Derived Peptide, International Journal of Peptide Research and Therapeutics (2019)
57. High Glucose Affects the Cytotoxic Potential of Rapamycin, Metformin and Hydrogen Peroxide in Cultured Human Mesenchymal Stem Cells, Current Molecular Medicine (2019)
58. Human Menstrual Blood-Derived Stromal/Stem Cells Modulate Functional Features of Natural Killer Cells, Scientific Reports (2019)
59. Integrational Analysis of Mirnas Data Sets As a Plausible Missing Linker Between Epstein-Barr Virus and Vitamin D in Relapsing Remitting Ms Patients, Gene (2019)
60. The Interplay Between Vitamin D and Viral Infections, Reviews in Medical Virology (2019)
61. All-Trans Retinoic Acid in Combination With Sodium Butyrate Enhances Specific Monoclonal Antibody Productivity in Recombinant Cho Cell Line, Bioprocess and Biosystems Engineering (2018)
62. Blocking of Opioid Receptors in Experimental Formaline-Inactivated Respiratory Syncytial Virus (Fi-Rsv) Immunopathogenesis: From Beneficial to Harmful Impacts, Medical Microbiology and Immunology (2018)
63. Cbpm and Cbpg of Streptococcus Pneumoniae Elicit a High Protection in Mice Challenged With a Serotype 19F Pneumococcus, Iranian Journal of Allergy# Asthma and Immunology (2018)
64. Correction To: Blocking of Opioid Receptors in Experimental Formaline-Inactivated Respiratory Syncytial Virus (Fi-Rsv) Immunopathogenesis: From Beneficial to Harmful Impacts (Medical Microbiology and Immunology, (2018), 207, 2, (105-115), 10.1007/S00430-017-0531-0), Medical Microbiology and Immunology (2018)
65. Differential Effects of Inhibitory and Stimulatory Anti-Her2 Monoclonal Antibodies on Akt/Erk Signaling Pathways, Asian Pacific Journal of Cancer Prevention (2018)
66. Effects of Cannabinoid Receptor Type 2 in Respiratory Syncytial Virus Infection in Human Subjects and Mice, Virulence (2018)
67. Enhancement of Monoclonal Antibody Production After Single and Combination Treatment of the Hybridoma Cells With All-Trans Retinoic Acid and Docosahexaenoic Acid: An in Vitro and in Vivo Study, International Immunopharmacology (2018)
68. Hersintuzumab: A Novel Humanized Anti-Her2 Monoclonal Antibody Induces Potent Tumor Growth Inhibition, Investigational New Drugs (2018)
69. Immune Function of Plasmacytoid Dendritic Cells, Natural Killer Cells, and Their Crosstalk in Hbv Infection, Reviews in Medical Virology (2018)
70. Immunization With Her2 Extracellular Subdomain Proteins Induces Cellular Response and Tumor Growth Inhibition in Mice, Immunotherapy (2018)
71. Inhibition of Tumor Growth by Mouse Ror1 Specific Antibody in a Syngeneic Mouse Tumor Model, Immunology Letters (2018)
72. Investigation of the Cellular Immune Response to Recombinant Fragments of Filamentous Hemagglutinin and Pertactin of Bordetella Pertussis in Balb/C Mice, Journal of Interferon and Cytokine Research (2018)
73. Menstrual Blood-Derived Stromal Stem Cells Augment Cd4+ T Cells Proliferation, Avicenna Journal of Medical Biotechnology (2018)
74. The Role of Cannabinoid Receptor 1 in the Immunopathology of Respiratory Syncytial Virus, Viral Immunology (2018)
75. Antibody Response to Human Extracellular Her2 Subdomain Proteins in Mice, Iranian Journal of Immunology (2017)
76. Cd73 Specific Sirna Loaded Chitosan Lactate Nanoparticles Potentiate the Antitumor Effect of a Dendritic Cell Vaccine in 4T1 Breast Cancer Bearing Mice, Journal of Controlled Release (2017)
77. Construction of a Hepatitis B Virus Neutralizing Chimeric Monoclonal Antibody Recognizing Escape Mutants of the Viral Surface Antigen (Hbsag), Antiviral Research (2017)
78. Effects of Viral Peptide Presentation on Cd4+ T Cell Responses to Mhc Class Ii-Restricted Tumor Peptides, International Journal of Cancer Management (2017)
79. Epitope Mapping of Human Her2 Specific Mouse Monoclonal Antibodies Using Recombinant Extracellular Subdomains, Asian Pacific Journal of Cancer Prevention (2017)
80. Polyclonal Antibody Against Different Extracellular Subdomains of Her2 Induces Tumor Growth Inhibition in Vitro, Iranian Journal of Immunology (2017)
81. The Association of the Vitamin D Status With the Persistence of Anti-Hbs Antibody at 20 Years After Primary Vaccination With Recombinant Hepatitis B Vaccine in Infancy, Clinics and Research in Hepatology and Gastroenterology (2017)
82. Variation of Housekeeping Genes in Clinical Isolates and Vaccine Strains of Bordetella Pertussis, Clinical Laboratory (2017)
83. A Shift in the Balance of T17 and Treg Cells in Menstrual Blood of Women With Unexplained Recurrent Spontaneous Abortion, Journal of Reproductive Immunology (2016)
84. Analysis of Knowledge, Attitudes, and Prevalence of Hepatitis B and C Seromarkers Among Barbers in Tehran, Hepatitis Monthly (2016)
85. Antibody Response to Her2 Extracellular Domain and Subdomains in Mouse Following Dna Immunization, Tumor Biology (2016)
86. Comparative Human and Mouse Antibody Responses Against Tetanus Toxin at Clonal Level, Journal of Immunotoxicology (2016)
87. Downregulation of Cd73 in 4T1 Breast Cancer Cells Through Sirna-Loaded Chitosan-Lactate Nanoparticles, Tumor Biology (2016)
88. Ebv and Vitamin D Status in Relapsing-Remitting Multiple Sclerosis Patients With a Unique Cytokine Signature, Medical Microbiology and Immunology (2016)
89. Evaluation of Ebv Transformation of Human Memory B-Cells Isolated by Facs and Macs Techniques, Journal of Immunotoxicology (2016)
90. Fibrinogen and Fibronectin Binding Activity and Immunogenic Nature of Choline Binding Protein M, Iranian Journal of Public Health (2016)
91. Hepatitis B Immunopathogenesis and Immunotherapy, Immunotherapy (2016)
92. Localization of Immunodominant Epitopes Within the “A” Determinant of Hepatitis B Surface Antigen Using Monoclonal Antibodies, Archives of Virology (2016)
93. Opioids and Viral Infections: A Double-Edged Sword, Frontiers in Microbiology (2016)
94. Restricted Antibody Response to Bordetella Pertussis Filamentous Hemagglutinin Induced by Whole-Cell and Acellular Pertussis Vaccines, Infectious Diseases (2016)
95. Synergistic Induction of Apoptosis in B-Cell Chronic Lymphocytic Leukemia Cells After Treatment With All-Trans Retinoic Acid in Combination With Interleukin-21 and Rituximab, Journal of Cancer Research and Therapeutics (2016)
96. The Combined Effects of All-Trans-Retinoic Acid and Docosahexaenoic Acid on the Induction of Apoptosis in Human Breast Cancer Mcf-7 Cells, Journal of Cancer Research and Therapeutics (2016)
97. Vitamin a Decreases Cytotoxicity of Oxidized Low-Density Lipoprotein in Patients With Atherosclerosis, Immunological Investigations (2016)
98. Administration of Naloxone in Combination With Recombinant Plasmodium Vivax Ama-1 in Balb/C Mice Induces Mixed Th1/Th2 Immune Responses, Parasite Immunology (2015)
99. All-Trans-Retinoic Acid Differentially Regulates Proliferation of Normal and Leukemic B Cells From Different Subsets of Chronic Lymphocytic Leukemia, Nutrition and Cancer (2015)
100. Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine, Iranian Journal of Allergy# Asthma and Immunology (2015)
101. Interaction of Bordetella Pertussis Filamentous Hemagglutinin With Human Tlr2: Identification of the Tlr2-Binding Domain, APMIS (2015)
102. Leishmania Tarentolae Secreting the Sand Fly Salivary Antigen Ppsp15 Confers Protection Against Leishmania Major Infection in a Susceptible Balb/C Mice Model, Molecular Immunology (2015)
103. Menstrual Blood Contains Immune Cells With Inflammatory and Anti-Inflammatory Properties, Journal of Obstetrics and Gynaecology Research (2015)
104. Molecular Characterization of Murine Monoclonal Antibody Variable Regions Specific for Hepatitis B Surface Antigen, Viral Immunology (2015)
105. Preliminary Assessment of Various Additives on the Specific Reactivity of Anti- Rhbsag Monoclonal Antibodies, Avicenna Journal of Medical Biotechnology (2015)
106. Receptor Tyrosine Kinase-Like Orphan Receptor 1: A Novel Target for Cancer Immunotherapy, Expert Opinion on Therapeutic Targets (2015)
107. Spontaneous Immunity Against the Receptor Tyrosine Kinase Ror1 in Patients With Chronic Lymphocytic Leukemia, PLoS ONE (2015)
108. Targeted Delivery of 5-Fluorouracil With Monoclonal Antibody Modified Bovine Serum Albumin Nanoparticles, Iranian Journal of Pharmaceutical Research (2015)
109. Comparative Effectiveness of Hand and Ultrasonic Instrumentations in Root Surface Planing in Vitro, Journal of Clinical Periodontology (2004)