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Preferential Solvation of Some Corticosteroids in {Ethanol (1) + Water (2)} Mixtures at 298.2 K Publisher



Jouyban A1, 2 ; Martinez F4
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 51664, Iran
  2. 2. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Chemistry, University of North Texas, Denton, 76203-5070, TX, United States
  4. 4. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Universidad Nacional de Colombia, Sede Bogota, Cra. 30 No. 45-03, Bogota D. C., Colombia

Source: Journal of Molecular Liquids Published:2020


Abstract

The equilibrium solubility of three corticosteroids, namely, budesonide, hydrocortisone and prednisolone in some {ethanol (1) + water (2)} mixtures as expressed in mole fraction at 298.2 K was calculated from reported solubility values expressed in molarity scale. Further, by using the inverse Kirkwood-Buff integrals is observed that these drugs are preferentially solvated by water molecules in water-rich mixtures and apparently also in ethanol-rich mixtures but preferentially solvated by ethanol molecules in mixtures of similar proportions of the solvents. © 2020 Elsevier B.V.
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