Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Solubility of Ketoconazole in 1,4-Dioxane + Water Mixtures at T = (293.2 to 313.2) K Publisher



Barzegarjalali M1, 7 ; Mazaher Haji Agha E2 ; Adibkia K1, 7 ; Martinez F3 ; Kuentz M4 ; Jouyban A5, 6, 7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia – Sede Bogota, Cra. 30 No. 45-03, Bogota, D.C., Colombia
  4. 4. Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstr. 30, Muttenz, 4132, Switzerland
  5. 5. Pharmaceutical Analysis Research Center, Tabriz University of Medical sciences, Tabriz, Iran
  6. 6. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Journal of Molecular Liquids Published:2020


Abstract

The solubility of ketoconazole was measured in aqueous mixtures of 1,4-dioxane at T = (293.2 to 313.2) K using the shake flask method. To mathematically represent the generated solubility data, combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K), van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, UNIQUAC, and NRTL models were applied. Differences of experimental and predicted values were expressed as the percentage of averaged relative deviation (% ARD). Apparent thermodynamic quantities of ketoconazole dissolution and mixing were reported at harmonic temperature. Moreover, the dissolution mechanism of ketoconazole was studied in 1,4-dioxane + water mixtures. Based on the inverse Kirkwood-Buff integrals, the preferential solvation parameters were calculated and it is observed that ketoconazole is preferentially solvated by water in water-rich and 1,4-dioxane-rich mixtures. © 2018 Elsevier B.V.
Related Docs
View other Related Docs
1. Measurement and Modelling of the Solubility for Ketoconazole in {Acetonitrile + Water} Mixtures at T = (293.2 to 313.2) K, Physics and Chemistry of Liquids (2021)
2. The Solubility of Ketoconazole in Binary Carbitol + Water Mixtures at T = (293.2–313.2) K, Journal of Molecular Liquids (2020)
3. Solubility of Mesalazine in {1-Propanol/Water} Mixtures at Different Temperatures, Journal of Molecular Liquids (2020)
4. Solubility of Mesalazine in {Acetonitrile + Water} Mixtures at Various Temperatures, Physics and Chemistry of Liquids (2021)
5. Solubility and Thermodynamic Properties of Mesalazine in {2-Propanol + Water} Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)
6. Dissolution Thermodynamics and Preferential Solvation of Ketoconazole in Some {Ethanol (1) + Water (2)} Mixtures, Journal of Molecular Liquids (2020)
7. Mesalazine Solubility in Propylene Glycol and Water Mixtures at Various Temperatures Using a Laser Monitoring Technique, Journal of Molecular Liquids (2020)
8. Solubility of 5-Aminosalicylic Acid in N-Methyl-2-Pyrrolidone + Water Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)
Experts (# of related papers)
Alireza Foroumadi (1)
Other Related Docs
9. Solubility of Meloxicam in (Carbitol® + Water) Mixtures: Determination, Correlation, Dissolution Thermodynamics and Preferential Solvation, Journal of Molecular Liquids (2021)
10. Solubility of 5-Aminosalicylic Acid in {N-Methyl-2-Pyrrolidone + Ethanol} Mixtures at T = (293.2 to 313.2) K, Journal of Molecular Liquids (2020)
11. Further Numerical Analyses on the Solubility of Diazepam in Aqueous Tert-Butanol Mixtures, Physics and Chemistry of Liquids (2021)
12. Predicting the Solubility, Thermodynamic Properties and Preferential Solvation of Sulphamethazine in {Acetonitrile + Water} Mixtures Using a Minimum Number of Experimental Data Points, Physics and Chemistry of Liquids (2021)
13. Mesalazine Solubility in the Binary Mixtures of Ethanol and Water at Various Temperatures, Physics and Chemistry of Liquids (2021)
14. Solubility of Mesalazine in Polyethylene Glycol 400 + Water Mixtures at Different Temperatures, Journal of Molecular Liquids (2020)
15. Preferential Solvation of Some Corticosteroids in {Ethanol (1) + Water (2)} Mixtures at 298.2 K, Journal of Molecular Liquids (2020)
16. Further Comments on “Experimental Measurements, Equilibrium Study and Model Correlation of Methyl Paraben in Ethanol and Methanol Aqueous Solutions From = (293.15 to 323.15) K”, Journal of Molecular Liquids (2020)
17. Preferential Solvation of 4-(4-Ethoxyphenyl)-5-(3,4,5-Trimethoxybenzoyl)-3,4-Dihydropyrimidin-2(1H)-One in {Peg 400 (1) + Water (2)} Mixtures, Physics and Chemistry of Liquids (2021)
18. Simulation of Mesalazine Solubility in the Binary Solvents at Various Temperatures, Journal of Molecular Liquids (2022)
19. Solubilization of Naproxen: Experimental Data and Computational Tools, Journal of Molecular Liquids (2019)
20. Measurement and Modeling of Sodium Chloride Solubility in Binary Mixtures of Water + Polyethylene Glycol 400 at Various Temperatures, Journal of Molecular Liquids (2020)
21. Comments Concerning “Solvent Effect and Preferential Solvation of Cefpiramide in Cosolvent Plus Water Mixtures”, Journal of Molecular Liquids (2019)
22. Computational Tools for Solubility Prediction of Celecoxib in the Binary Solvent Systems, Journal of Molecular Liquids (2020)
23. A Laser Monitoring Technique for Determination of Mesalazine Solubility in Propylene Glycol and Ethanol Mixtures at Various Temperatures, Journal of Molecular Liquids (2020)