The Toxicity and Therapeutic Effects of Single-And Multi-Wall Carbon Nanotubes on Mice Breast Cancer

The Toxicity and Therapeutic Effects of Single-And Multi-Wall Carbon Nanotubes on Mice Breast Cancer Publisher Pubmed

Kavosi A¹ ; Hosseini Ghale Noei S¹ ; Madani S¹ ; Khalighfard S^{2, 3} ; Khodayari S³ ; Khodayari H^{3, 4} ; Mirzaei M⁵ ; Kalhori MR³ ; Yavarian M⁶ ; Alizadeh AM^{3, 4} ; Falahati M⁷

Show Affiliations

1. Department of Cellular and Molecular Biology, Faculty of Advanced Sciences and Technology, Islamic Azad University, Pharmaceutical Science Branch, Tehran, Iran
2. Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran
3. Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Breast Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran
6. Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
7. Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

Source: Scientific Reports Published:2018

Abstract

Herein, we have investigated the toxicity of SWCNTs and MWCNTs in vitro and in vivo, and assessed their therapeutic effects on a typical animal model of breast cancer in order to obtain: first, the cytotoxicity effects of CNTs on MC4L2 cell and mice, second the impact of CNTs on ablation of breast tumor. CNTs especially SWCNTs were toxic to organs and induced death at high dosages. In this case, some of the liver cells showed a relative shrinkage which was also confirmed by Annexin test in MC4L2 cells. Moreover, CNTs decreased the tumor volume. BCL2 gene was down-regulated, and BAX and Caspase-3 were also up-regulated in the treated groups with CNTs. As a result, CNTs especially MWCNT in lower dosages can be used as a promising drug delivery vehicle for targeted therapy of abnormal cells in breast cancer. © 2018 The Author(s).

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Alimohammad Alizadeh (18)

Shaban Alizadeh (1)

Style	Citing Format
MLA	Kavosi A, et al.. "The Toxicity and Therapeutic Effects of Single-And Multi-Wall Carbon Nanotubes on Mice Breast Cancer." Scientific Reports, vol. 8, no. 1, 2018, pp. -.
APA	Kavosi A, Hosseini Ghale Noei S, Madani S, Khalighfard S, Khodayari S, Khodayari H, Mirzaei M, Kalhori MR, Yavarian M, Alizadeh AM, Falahati M (2018). The Toxicity and Therapeutic Effects of Single-And Multi-Wall Carbon Nanotubes on Mice Breast Cancer. Scientific Reports, 8(1), -.
Chicago	Kavosi A, Hosseini Ghale Noei S, Madani S, Khalighfard S, Khodayari S, Khodayari H, Mirzaei M, et al.. "The Toxicity and Therapeutic Effects of Single-And Multi-Wall Carbon Nanotubes on Mice Breast Cancer." Scientific Reports 8, no. 1 (2018): -.
Harvard	Kavosi A et al. (2018) 'The Toxicity and Therapeutic Effects of Single-And Multi-Wall Carbon Nanotubes on Mice Breast Cancer', Scientific Reports, 8(1), pp. -.
Vancouver	Kavosi A, Hosseini Ghale Noei S, Madani S, Khalighfard S, Khodayari S, Khodayari H, et al.. The Toxicity and Therapeutic Effects of Single-And Multi-Wall Carbon Nanotubes on Mice Breast Cancer. Scientific Reports. 2018;8(1):-.
BibTex	@article{ author = {Kavosi A and Hosseini Ghale Noei S and Madani S and Khalighfard S and Khodayari S and Khodayari H and Mirzaei M and Kalhori MR and Yavarian M and Alizadeh AM and Falahati M}, title = {The Toxicity and Therapeutic Effects of Single-And Multi-Wall Carbon Nanotubes on Mice Breast Cancer}, journal = {Scientific Reports}, volume = {8}, number = {1}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Kavosi A AU - Hosseini Ghale Noei S AU - Madani S AU - Khalighfard S AU - Khodayari S AU - Khodayari H AU - Mirzaei M AU - Kalhori MR AU - Yavarian M AU - Alizadeh AM AU - Falahati M TI - The Toxicity and Therapeutic Effects of Single-And Multi-Wall Carbon Nanotubes on Mice Breast Cancer JO - Scientific Reports VL - 8 IS - 1 SP - EP - PY - 2018 ER -

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