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The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019 Publisher Pubmed



Da Cunha AR1 ; Compton K2 ; Xu R2, 3 ; Mishra R4 ; Drangsholt MT4, 5 ; Antunes JLF1 ; Kerr AR6 ; Acheson AR2 ; Lu D2 ; Wallace LE2 ; Kocarnik JM2 ; Fu W2 ; Dean FE2, 7 ; Pennini A2 Show All Authors
Authors
  1. Da Cunha AR1
  2. Compton K2
  3. Xu R2, 3
  4. Mishra R4
  5. Drangsholt MT4, 5
  6. Antunes JLF1
  7. Kerr AR6
  8. Acheson AR2
  9. Lu D2
  10. Wallace LE2
  11. Kocarnik JM2
  12. Fu W2
  13. Dean FE2, 7
  14. Pennini A2
  15. Henrikson HJ2, 8
  16. Alam T2
  17. Ababneh E9
  18. Abdelsalam S10
  19. Abdoun M11
  20. Abidi H12
  21. Abubaker Ali H13
  22. Abugharbieh E14
  23. Adane TD15
  24. Addo IY16, 17
  25. Ahmad A18
  26. Ahmad S19
  27. Ahmed Rashid T20
  28. Akonde M21
  29. Al Hamad H22, 23
  30. Alahdab F24
  31. Alimohamadi Y25
  32. Alipour V26, 27
  33. Almaweri SA28
  34. Alsharif U29
  35. Ansarimoghaddam A30
  36. Anwar SL31
  37. Anyasodor AE32
  38. Arabloo J26
  39. Aravkin AY2, 33, 34
  40. Aruleba RT35
  41. Asaad M36
  42. Ashraf T37
  43. Athari SS38
  44. Attia S39
  45. Azadnajafabad S40
  46. Azangoukhyavy M40, 41
  47. Badar M42
  48. Baghcheghi N43
  49. Banach M44, 45
  50. Bardhan M46, 47
  51. Barqawi HJ14
  52. Bashir NZ48
  53. Bashiri A49
  54. Benzian H50
  55. Bernabe E51
  56. Bhagat DS52
  57. Bhojaraja VS53
  58. Bjorge T54, 55
  59. Bouaoud S56, 57
  60. Braithwaite D58, 59
  61. Briko NI60
  62. Calina D61
  63. Carreras G62
  64. Chakraborty PA63
  65. Chattu VK64, 65
  66. Chaurasia A66
  67. Chen MX67
  68. Cho WCS68
  69. Chu DT69
  70. Chukwu IS70
  71. Chung E2
  72. Cruzmartins N71, 72
  73. Dadras O54, 73
  74. Dai X2, 34
  75. Dandona L2, 74, 75
  76. Dandona R2, 34, 74
  77. Daneshpajouhnejad P76, 77
  78. Darvishi Cheshmeh Soltani R78
  79. Darwesh AM79
  80. Debela SA80
  81. Derbew Molla M81
  82. Dessalegn FN82
  83. Dianatinasab M83, 84
  84. Digesa LE85
  85. Dixit SG86
  86. Dixit A87
  87. Djalalinia S88
  88. El Sayed I89
  89. El Tantawi M90
  90. Enyew DB91
  91. Erku DA92
  92. Ezzeddini R93
  93. Fagbamigbe AF94, 95
  94. Falzone L96, 97
  95. Fetensa G98
  96. Fukumoto T99
  97. Gaewkhiew P100, 101
  98. Gallus S102
  99. Gebrehiwot M103
  100. Ghashghaee A104
  101. Gill PS105
  102. Golechha M106
  103. Goleij P107
  104. Gomez RS108
  105. Gorini G109
  106. Guimaraes ALS110
  107. Gupta B111
  108. Gupta S112
  109. Gupta VB113
  110. Gupta VK114
  111. Hajmirzaian A115, 116
  112. Halboub ES117, 118
  113. Halwani R14, 119
  114. Hanif A120
  115. Hariyani N121, 122
  116. Harorani M123
  117. Hasani H124
  118. Hassan AM36
  119. Hassanipour S125, 126
  120. Hassen MB2, 127
  121. Hay SI2, 34
  122. Hayat K128, 129
  123. Herreraserna BY130
  124. Holla R131
  125. Horita N132, 133
  126. Hosseinzadeh M134, 135
  127. Hussain S136, 137
  128. Ilesanmi OS138, 139
  129. Ilic IM140
  130. Ilic MD141
  131. Isola G142
  132. Jaiswal A143
  133. Jani CT144
  134. Javaheri T145
  135. Jayarajah U146, 147
  136. Jayaram S148
  137. Joseph N149
  138. Kadashetti V150
  139. Kandaswamy E151
  140. Karanth SD152
  141. Karaye IM153
  142. Kauppila JH154, 155
  143. Kaur H74
  144. Keykhaei M40, 156
  145. Khader YS157
  146. Khajuria H158
  147. Khanali J40, 41
  148. Khatib MN159
  149. Khayat Kashani HR160
  150. Khazeei Tabari MA161, 162
  151. Kim MS163, 164
  152. Kompani F165
  153. Koohestani HR166
  154. Kumar GA74
  155. Kurmi OP167, 168
  156. La Vecchia C169
  157. Lal DK74
  158. Landires I170, 171
  159. Lasrado S172
  160. Ledda C173
  161. Lee YH174
  162. Libra M97
  163. Lim SS2, 34
  164. Listl S175, 176
  165. Lopukhov PD60
  166. Mafi AR177
  167. Mahumud RA178
  168. Malik AA120, 179
  169. Mathur MR180, 181
  170. Maulud SQ182
  171. Meena JK183
  172. Mehrabi Nasab E184
  173. Mestrovic T2, 185
  174. Mirfakhraie R186
  175. Misganaw A34, 187
  176. Misra S188
  177. Mithra P149
  178. Mohammad Y189
  179. Mohammadi M190
  180. Mohammadi E192
  181. Mokdad AH2, 34
  182. Moni MA193
  183. Moraga P194
  184. Morrison SD195
  185. Mozaffari HR196
  186. Mubarik S197
  187. Murray CJL2, 34
  188. Nair TS198
  189. Narasimha Swamy S199
  190. Narayana AI200
  191. Nassereldine H2
  192. Natto ZS201, 202
  193. Nayak BP158
  194. Negru SM203
  195. Nggada HA204, 205
  196. Nouraei H206
  197. Nunezsamudio V207, 208
  198. Oancea B209
  199. Olagunju AT210, 211
  200. Omar Bali A212
  201. Padronmonedero A213
  202. Padubidri JR214
  203. Pandey A74
  204. Pardhan S215
  205. Patel J216, 217
  206. Pezzani R218, 219
  207. Piracha ZZ220
  208. Rabiee N221, 222
  209. Radhakrishnan V223
  210. Radhakrishnan RA200
  211. Rahmani AM224
  212. Rahmanian V225
  213. Rao CR226
  214. Rao SJ227
  215. Rath GK228
  216. Rawaf DL229, 230
  217. Rawaf S231, 232
  218. Rawassizadeh R233
  219. Razeghinia MS234, 235
  220. Rezaei N40
  221. Rezaei N40
  222. Rezaei N40
  223. Rezapour A26
  224. Riad A239, 240
  225. Roberts TJ241, 242
  226. Romerorodriguez E243
  227. Roshandel G244
  228. Manjula S245
  229. Chandan SN245
  230. Saddik B246
  231. Saeb MR247
  232. Saeed U220, 248
  233. Safaei M249
  234. Sahebazzamani M250, 251
  235. Sahebkar A252, 253
  236. Salek Farrokhi A254
  237. Samy AM255, 256
  238. Santricmilicevic MM140, 257
  239. Sathian B22, 258
  240. Satpathy M259, 260
  241. Sekerija M261, 262
  242. Senthilkumaran S263
  243. Seylani A264
  244. Shafaat O265, 266
  245. Shahsavari HR267
  246. Shamsoddin E268, 269
  247. Sharew MM270
  248. Sharifirad J271
  249. Shetty JK272
  250. Shivakumar KM273
  251. Shobeiri P192, 274
  252. Shorofi SA275, 276
  253. Shrestha S277
  254. Siddappa Malleshappa SK278
  255. Singh P279
  256. Singh JA280, 281
  257. Singh G282, 283
  258. Sinha DN284, 285
  259. Solomon Y286
  260. Suleman M287, 288
  261. Suliankatchi Abdulkader R289
  262. Taheri Abkenar Y290
  263. Talaat IM14, 291
  264. Tan KK292
  265. Tbakhi A293
  266. Thiyagarajan A294
  267. Tiyuri A295, 296
  268. Tovanipalone MR297, 298
  269. Unnikrishnan B299
  270. Vo B300
  271. Volovat SR301, 302
  272. Wang C303
  273. Westerman R304
  274. Wickramasinghe ND305
  275. Xiao H306, 307
  276. Yu C197
  277. Yuce D308
  278. Yunusa I309
  279. Zadnik V310
  280. Zare I311
  281. Zhang ZJ312
  282. Zoladl M313
  283. Force LM2, 34, 314
  284. Hugo FN315

Source: JAMA Oncology Published:2023


Abstract

Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. Objective: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. Evidence Review: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. Findings: In 2019, 370000 (95% uncertainty interval [UI], 338000-401000) cases and 199000 (95% UI, 181000-217000) deaths for LOC and 167000 (95% UI, 153000-180000) cases and 114000 (95% UI, 103000-126000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. Conclusions and Relevance: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts. © 2023 American Medical Association. All rights reserved.
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