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Transition Metal-Catalyzed Dual C−H Activation/Annulation Reactions Involving Internal Alkynes Publisher Pubmed

Summary: Can alkynes create complex molecules? A study found dual alkyne reactions produce bioactive compounds efficiently, advancing drug and material development. #DrugSynthesis #OrganicChemistry

Doraghi F1 ; Karimtabar MS1, 2 ; Ghasemi M3 ; Larijani B1 ; Mahdavi M1
Authors

Source: Chemical Record Published:2024


Abstract

Recently, transition metal-catalyzed ortho-C−H bond activation/annulations involving two internal alkyne molecules have been extensively used to synthesize highly substituted polycyclic aromatic scaffolds. Such reactions have emerged as a powerful atom and step-economical strategy for the assembly of multifunctional bioactive molecules. In this context, we focused on the recent achievements of dual C−H bond activation/annulations, as well as functionalization reactions involving diaryl/alkyl alkynes. © 2024 The Chemical Society of Japan and Wiley-VCH GmbH.
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