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Transition Metal-Catalyzed Dual C−H Activation/Annulation Reactions Involving Internal Alkynes Publisher Pubmed



Doraghi F1 ; Karimtabar MS1, 2 ; Ghasemi M3 ; Larijani B1 ; Mahdavi M1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  3. 3. Natural and Medical Sciences Research Center (NMSRC), University of Nizwa, Nizwa, Oman

Source: Chemical Record Published:2024


Abstract

Recently, transition metal-catalyzed ortho-C−H bond activation/annulations involving two internal alkyne molecules have been extensively used to synthesize highly substituted polycyclic aromatic scaffolds. Such reactions have emerged as a powerful atom and step-economical strategy for the assembly of multifunctional bioactive molecules. In this context, we focused on the recent achievements of dual C−H bond activation/annulations, as well as functionalization reactions involving diaryl/alkyl alkynes. © 2024 The Chemical Society of Japan and Wiley-VCH GmbH.