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Long Non-Coding Rnas: Potential Players in Cardiotoxicity Induced by Chemotherapy Drugs Publisher Pubmed



Amrovani M1 ; Mohammadtaghizadeh M2 ; Aghaali MK3 ; Zamanifard S4 ; Alqasi A5 ; Sanei M6
Authors
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Authors Affiliations
  1. 1. High Institute for Education and Research in Transfusion Medicine, Tehran, Iran
  2. 2. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Departement of Cardiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Student Research Committee, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Cardiovascular Toxicology Published:2022


Abstract

One of the most important side effects of chemotherapy is cardiovascular complications, such as cardiotoxicity. Many factors are involved in the pathogenesis of cardiotoxicity; one of the most important of which is long non-coding RNAs (lncRNAs). lncRNA has 200–1000 nucleotides. It is involved in important processes such as cell proliferation, regeneration and apoptosis; today it is used as a prognostic and diagnostic factor. A, various drugs by acting on lncRNAs can affect cells. Therefore, by accurately identifying IncRNAs function, we can play an effective role in preventing the development of cardiotoxicity-induced chemotherapy drugs, and use them as a therapeutic strategy to improve clinical symptoms and increase patient survival. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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