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Modern Metal-Catalyzed and Organocatalytic Methods for Synthesis of Coumarin Derivatives: A Review Publisher Pubmed



Moghadam Farid S1 ; Seifinoferest B1 ; Gholamhosseyni M2 ; Larijani B1 ; Mahdavi M1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Chemistry, College of Chemistry, University of Tehran, Tehran, Iran

Source: Organic and Biomolecular Chemistry Published:2022


Abstract

Coumarin is an important pharmaceutical structural motif, abundantly found in numerous commonly used drugs. Compounds containing this core show a broad spectrum of medicinal properties and biological activities. The increasing importance and wide usages of coumarin derivatives have drawn attention to its synthetic methods, among which metal-catalyzed and organocatalytic methods have proved the most effective. Several metal-catalyzed and/or organocatalytic synthetic strategies for coumarin have been investigated and reported in recent decades. This review focuses on more recent reports on catalysis methods for synthesizing coumarin and coumarin-like structures (including light-mediated methods and nano-catalysts), exploring the mechanistic aspects, simplicity, efficiency, repeatability, and other advantages and disadvantages of these methods. © 2022 The Royal Society of Chemistry