Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Transition Metal-Catalyzed C−H Activation/Functionalization of 8-Methylquinolines Publisher Pubmed



Doraghi F1 ; Aghanour Ashtiani MM1 ; Ameli M2 ; Larijani B1 ; Mahdavi M1
Authors

Source: Chemical Record Published:2024


Abstract

8-Methylquinoline is regarded as an ideal substrate to participate in diversely C(sp3)−H functionalization reactions. The presence of the chelating nitrogen atom enables 8-methylquinoline to easily form cyclometallated complexes with various transition metals, leading to the selective synthesis of functionalized quinolines. Considering the great importance of quinoline cores in medicinal chemistry, in this review article, we have covered the publications related to the C−H activation and functionalization of 8-methylquinoline under transition metal catalysis during the last decade. © 2024 The Chemical Society of Japan and Wiley-VCH GmbH.
Related Docs
View other Related Docs
1. Combined Isocyanide-Based Multi-Component Ullmann-Type Reaction: An Efficient Access to Novel Nitrogen-Containing Pentacyclic Compounds, Molecular Diversity (2015)
2. Recent Advances in the Use of 2-Aminobenzyl Alcohols in the Synthesis of Quinolines, Quinazolines and Other N-Heterocycles, Advanced Synthesis and Catalysis (2024)
3. Novel Tacrine-Based Acetylcholinesterase Inhibitors As Potential Agents for the Treatment of Alzheimer’S Disease: Quinolotacrine Hybrids, Molecular Diversity (2022)
Experts (# of related papers)
View all Related Experts
Mohammad Mahdavi (10)
Tahmineh Akbarzadeh (3)
Other Related Docs
4. Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones, New Journal of Chemistry (2018)
5. Efficient Synthesis of Novel 2-(2-Chloroquinolin-3-Yl)Imidazo[1,2-A]Pyridin-3-Amine Derivatives, Journal of the Chinese Chemical Society (2021)
6. Novel Tacrine-Based Pyrano[3’,4’:5,6]Pyrano[2,3-B]Quinolinones: Synthesis and Cholinesterase Inhibitory Activity, Archiv der Pharmazie (2016)
7. Green Synthesis of 2-((2-Aryl-3-Oxoisoindolin-1-Yl)Methyl)Quinazolin-4(3H)-Ones Via Sequential Condensation, Sp3 C–H Bond Functionalization and Cyclization, Tetrahedron Letters (2018)
8. Synthesis of Novel Fused Quinazolinone Derivatives, Molecular Diversity (2016)
9. Ethyl 4-Hydroxy-2-Oxo-1,2-Dihydroquinoline-3-Carboxylate in the Smiles Rearrangement Reaction: Straightforward Synthesis of Amino Acid Derived Quinolin-2(1H)-One Enamines, Molecular Diversity (2023)
10. Copper-Mediated Direct Cyanatation of Benzamides: A New Approach to the Synthesis of Quinazolinediones, European Journal of Organic Chemistry (2020)
11. C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs), Asian Journal of Organic Chemistry (2021)