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Transition Metal-Catalyzed C−H Activation/Functionalization of 8-Methylquinolines Publisher Pubmed



Doraghi F1 ; Aghanour Ashtiani MM1 ; Ameli M2 ; Larijani B1 ; Mahdavi M1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, Tehran, Iran

Source: Chemical Record Published:2024


Abstract

8-Methylquinoline is regarded as an ideal substrate to participate in diversely C(sp3)−H functionalization reactions. The presence of the chelating nitrogen atom enables 8-methylquinoline to easily form cyclometallated complexes with various transition metals, leading to the selective synthesis of functionalized quinolines. Considering the great importance of quinoline cores in medicinal chemistry, in this review article, we have covered the publications related to the C−H activation and functionalization of 8-methylquinoline under transition metal catalysis during the last decade. © 2024 The Chemical Society of Japan and Wiley-VCH GmbH.