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Solubility of Sildenafil Citrate in the Binary Mixtures of Ethylene Glycol and Water at Different Temperatures Publisher



Hatefi A1 ; Rahimpour E2, 3 ; Ghafourian T4 ; Martinez F5 ; Barzegarjalali M6 ; Jouyban A2, 7
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. School of Life Sciences, University of Sussex, Brighton, BN1 9QG, United Kingdom
  5. 5. Grupo de Investigaciones Farmaceutico-Fisicoquimicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia – Sede Bogota, Cra. 30 No. 45-03, Bogota, D.C., Colombia
  6. 6. Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Molecular Liquids Published:2020


Abstract

The aim of this work is to investigate the solubility behavior of sildenafil citrate (SC) in the binary mixtures of ethylene glycol and water at different temperatures in the range of 293.2–313.2 K. The generated data are correlated with some linear and non-linear cosolvency models including the van't Hoff, the double log-log, the mixture response surface, Yalkowsky, Jouyban-Acree, Jouyban-Acree-van't Hoff, and the modified Wilson models. The mean relative deviations (MRD%) of the back-calculated solubility for each applied models are computed as an accuracy criterion. Density data measured for SC saturated mixtures as another physico-chemical property are also correlated with the Jouyban-Acree model and the results are discussed. Furthermore, apparent thermodynamic properties for SC dissolution process are computed by using van't Hoff and Gibbs equations. © 2019 Elsevier B.V.
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