Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Substituted 2H-Azirine Derivatives - Versatile Reagents to Access Skeletal Diversity Publisher



Farivar M1 ; Peirow R2 ; Iraji A3, 4 ; Mahdavi M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
  3. 3. Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Journal of Molecular Structure Published:2025


Abstract

2H-Azirines, a unique class of cyclic imines, have gained significant attention in the field of organic chemistry due to their remarkable reactivity and versatility in synthetic applications. These strained three-membered rings act as valuable synthons for constructing diverse nitrogen-containing heterocyclic frameworks, playing a pivotal role in drug discovery and materials science. 2H-Azirines readily undergo a wide range of transformations, including nucleophilic additions, cycloaddition reactions, and ring-opening processes, which enable the formation of complex molecular architectures. This review presents a comprehensive overview of the various synthetic pathways involving 2H-azirines, emphasizing their applications in the development of complex heterocycles and bioactive compounds. By highlighting advancements, this review underscores the increasing significance of 2H-azirines as crucial intermediates in modern synthetic chemistry and their potential to drive innovation in drug design and related fields. © 2025 Elsevier B.V.