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Effects of Nano-Biphasic Calcium Phosphate Composite on Bioactivity and Osteoblast Cell Behavior in Tissue Engineering Applications Publisher



Ebrahimianhosseinabadi M1 ; Etemadifar M2 ; Ashrafizadeh F3
Authors
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Authors Affiliations
  1. 1. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, 81746-73441, Iran
  2. 2. Orthopedic Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran

Source: Journal of Medical Signals and Sensors Published:2016


Abstract

In this paper, preparation, bioactivity, and osteoblast cell behavior of cortical bone derived nano-biphasic calcium phosphate (nano-BCP) are presented. The calcined bovine bone samples with the addition of di-ammonium hydrogen phosphate were heated at 700°C for 100 min, and thus nano-BCP with the composition of 63/37 hydroxyapatite (HA)/β-tricalcium phosphate (β-TCP) was produced. Scanning electron microscopy (SEM) images, energy dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD) analysis of immersed samples in simulated body fluid (SBF) solution showed that a uniform layer was formed on the surface after 7 days with the chemical composition of HA. The results indicated that the nano-BCP sample developed excellent bioactivity after 28 days. The nano-BCP samples showed better cell proliferation compared to pure HA samples. After 7 days in cell culture, the prepared nano-BCP (HA/β-TCP) exhibited the maximum proliferation of the MG-63 osteoblast cells. © 2016 Journal of Medical Signals and Sensors.
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