Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Final Height in Children and Adolescents With Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis Publisher Pubmed



Hovsepian S1 ; Chegini R1 ; Alinia T1 ; Ghaheh HS2 ; Nouri R3 ; Hashemipour M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Medical Library and Information Sciences, School of Management and Medical Information Sciences, Health Information Technology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Hormones Published:2024


Abstract

Purpose: Considering the high prevalence of type 1 diabetes mellitus (T1DM) together with the importance of improved physical growth and the significance of promoting healthcare quality among T1DM children, this meta-analysis aims to determine mean final height in this population group. Methods: We systematically searched PubMed, EMBASE, Web of Science, Scopus, and Cochrane databases for all studies published until May 2023 and reviewed references of published articles. Meta-analytic procedures were used to estimate the effect size (mean final height Z-score) among T1DM children in a random effects model. Significance values, weighted effect sizes, 95% CIs, and tests of homogeneity of variance were calculated. The included studies consisted of data from 3274 patients. Results: The mean final height Z-score for T1DM children was -0.201 (n = 25 studies, 95% CI: -0.389, -0.013; I2 = 97%), -0.262 in males (n = 20 studies, 95% CI: -0.539, 0.015, I2 = 97.1%), and -0.218 in females (n = 18 studies, 95% CI: -0.436, 0, I2 = 94.2%). The non-significant negative association between age at diagnosis, HbA1c levels, and final height Z-score is suggested by the findings of the univariate meta-regression. Conclusion: Our findings indicated that children with T1DM have impaired linear growth and that monitoring of growth in these patient populations is an important issue in the management of T1DM. Due to a scarcity of studies providing data on the relationship between uncontrolled diabetes (increased HbA1c) and early diagnosis and final height, further investigation is warranted to determine whether there is indeed a correlation. Consequently, any conclusion regarding the association between uncontrolled diabetes (elevated HbA1c), early diagnosis of T1DM, and the increased risk of impaired linear growth or final height remains uncertain. © The Author(s), under exclusive licence to Hellenic Endocrine Society 2023.
Related Docs
View other Related Docs
1. Comparing Mizaj (Temperament) in Type 1 Diabetes Mellitus and Healthy Controls: A Case-Control Study, Journal of Research in Medical Sciences (2019)
2. Evaluating the Effectiveness of Peer-Based Intervention in Managing Type I Diabetes Mellitus Among Children and Adolescents: A Systematic Review, Medical Journal of the Islamic Republic of Iran (2016)
3. Trichomonas Vaginalis Infection and Risk of Cervical Neoplasia: A Systematic Review and Meta-Analysis, PLoS ONE (2023)
4. Trends in Incidence Rates of Childhood Type 1 Diabetes Mellitus: A Retrospective Study in Isfahan Province, Iran, Journal of Diabetes Investigation (2023)
5. Ultrasound Findings of Liver and Pancreas in Children With Type 1 Diabetes Mellitus: A Case-Control Study, Iranian Journal of Radiology (2024)
6. Anthropometric Indices Predicting Incident Type 2 Diabetes in an Iranian Population: The Isfahan Cohort Study, Diabetes and Metabolism (2013)
7. The Prevalence of Impaired Fasting Glucose and Type 2 Diabetes in a Population-Based Sample of Overweight/Obese Children in the Middle East, Pediatric Diabetes (2010)
8. Body Weight Changes and Diabetes Mellitus Incident: A Cohort Study From the Middle East, Journal of Preventive Medicine and Hygiene (2023)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (19)
Mahin Hashemipour (9)
Other Related Docs
9. Assessment of Caring Status for Patients With Type 2 Diabetes in Under Control Health Centers of Jarghoyee Region in Isfahan, Iran, Journal of Isfahan Medical School (2017)
10. The Product of Triglycerides and Glucose in Comparison With Fasting Plasma Glucose Did Not Improve Diabetes Prediction, Acta Diabetologica (2015)
11. Dietary Intake of Total, Animal and Plant Proteins and the Risk of Coronary Heart Disease and Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)
12. Online Self-Management Training and Play Therapy for Treating Behavioral Problems of Children With T1dm, Journal of Research and Health (2024)
13. The Visceral Adiposity Index in Comparison With Easily Measurable Anthropometric Markers Did Not Improve Prediction of Diabetes, Canadian Journal of Diabetes (2016)
14. Association of Anthropometric Measures With Cardiovascular Risk Factors and Metabolic Syndrome in Normal-Weight Children and Adolescents: The Caspian Iii Study, Obesity Facts (2013)
15. Bacterial Profile and Antimicrobial Resistance Patterns of Infected Diabetic Foot Ulcers in Iran: A Systematic Review and Meta-Analysis of Cross-Sectional Studies, International Journal of Lower Extremity Wounds (2022)
16. Progression to Impaired Glucose Metabolism in First-Degree Relatives of Patients With Type 2 Diabetes in Isfahan, Iran, Diabetes/Metabolism Research and Reviews (2009)
17. Variations in Diabetes Prevalence in Low-, Middle-, and High-Income Countries: Results From the Prospective Urban and Rural Epidemiological Study, Diabetes Care (2016)
18. Association of Anthropometric Indices With Continuous Metabolic Syndrome in Children and Adolescents: The Caspian-V Study, Eating and Weight Disorders (2018)
19. Validity of Triglyceride–Glucose Index As an Indicator for Metabolic Syndrome in Children and Adolescents: The Caspian-V Study, Eating and Weight Disorders (2018)
20. Incidence of Metabolic Syndrome and Its Risk Factors Among Type 2 Diabetes Clinic Attenders in Isfahan, Iran, Endokrynologia Polska (2012)
21. Adherence to the Healthy Eating Index and Alternative Healthy Eating Index Dietary Patterns and Mortality From All Causes, Cardiovascular Disease and Cancer: A Meta-Analysis of Observational Studies, Journal of Human Nutrition and Dietetics (2017)
22. Metabolic Syndrome in First Degree Relatives of Patients With Type 2 Diabetes: Incidence and Risk Factors, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2011)
23. Risk of Diabetes According to the Metabolic Health Status and Degree of Obesity, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
24. Prevalence and Related Risk-Factors of Peripheral Neuropathy in Children With Insulin-Dependent Diabetes Mellitus, Journal of Research in Medical Sciences (2013)
25. Comparison of Body Mass Index With Abdominal Obesity Indicators and Waist-To-Stature Ratio for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Obesity Research and Clinical Practice (2010)
26. Neighbourhood Socioeconomic Status and Overweight/Obesity: A Systematic Review and Meta-Analysis of Epidemiological Studies, BMJ Open (2019)
27. Seeing the Forest for the Trees: How to Interpret a Meta-Analysis Forest Plot, Journal of Advanced Nursing (2021)
28. Comparison of Dietary Intake Between Children With Type1 Diabetes Mellitus and Control Group, Iranian Journal of Diabetes and Lipid Disorders (2005)
29. Tri-Ponderal Mass Index and Body Mass Index in Prediction of Pediatric Metabolic Syndrome: The Caspian-V Study, Archives of Endocrinology and Metabolism (2020)
30. A Systematic Review and Meta-Analysis of the Prevalence of Malnutrition Among 6-14-Year-Old Children in Iran, International Journal of Preventive Medicine (2022)
31. Associations of Hip Circumference and Height With Incidence of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Acta Diabetologica (2012)
32. Association Between Sleep Duration and Diabetes Mellitus: Isfahan Healthy Heart Program, Nigerian Journal of Clinical Practice (2013)
33. First Report on the Validity of a Continuous Metabolic Syndrome Score As an Indicator for Metabolic Syndrome in a National Sample of Paediatric Population - the Caspian-Iii Study, Endokrynologia Polska (2013)
34. A Proposed Simplified Definition of Metabolic Syndrome in Children and Adolescents: A Global Perspective, BMC Medicine (2024)
35. Novel Anthropometric Indices for Predicting Type 2 Diabetes Mellitus, BMC Public Health (2024)
36. Gestational Diabetes Mellitus in Plymouth, U.K.: Prevalence, Seasonal Variation and Associated Factors, Journal of Reproductive Medicine for the Obstetrician and Gynecologist (2006)
37. Ramadan Fasting Among Adolescents With Type 1 Diabetes: A Systematic Review and Meta-Analysis, BMC Endocrine Disorders (2025)
38. Dexamethasone Stress Test: A Pilot Clinical Study for Identification of Individuals Highly Prone to Develop Type 2 Diabetes, Endocrine Practice (2018)
39. Association of Short Stature With Life Satisfaction and Self-Rated Health in Children and Adolescents: The Caspian-Iv Study, Journal of Pediatric Endocrinology and Metabolism (2016)
40. Effects of Gender and Height on the Oral Glucose Tolerance Test: The Isfahan Diabetes Prevention Study, Review of Diabetic Studies (2008)
41. Relationship Between Body Mass Index, Risk of Venous Thromboembolism and Pulmonary Embolism: A Systematic Review and Dose-Response Meta-Analysis of Cohort Studies Among Four Million Participants, Thrombosis Research (2020)
42. The Impact of Poor Glycemic Control on Lipid Profile Variables in Children With Type 1 Diabetes Mellitus, Journal of Education and Health Promotion (2019)
43. The Association Between Omentin and Diabetes: A Systematic Review and Meta-Analysis of Observational Studies, Diabetes, Metabolic Syndrome and Obesity (2019)
44. Statins Use and Risk of Breast Cancer Recurrence and Death: A Systematic Review and Meta-Analysis of Observational Studies, Journal of Pharmacy and Pharmaceutical Sciences (2016)
45. Patterns and Predictors of Long-Term Weight Change in Patients With Type 2 Diabetes Mellitus, Annals of Nutrition and Metabolism (2009)
46. Proportion of Toxin and Non-Toxin Virulence Factors of Staphylococcus Aureus Isolates From Diabetic Foot Infection: A Systematic Review and Meta-Analysis, BMC Microbiology (2024)
47. Prevalence, Incidence and Ecological Determinants of Diabetic Retinopathy in Iran: Systematic Review and Meta-Analysis, Journal of Ophthalmic and Vision Research (2019)
48. Comparison of Glycated Hemoglobin With Fasting Plasma Glucose in Definition of Glycemic Component of the Metabolic Syndrome in an Iranian Population, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2012)
49. Prevalence of Toxoplasma Gondii in Hiv-Infected Individuals in Iran: A Systematic Review and Meta-Analysis, Current HIV Research (2023)
50. Global Variation in Diabetes Diagnosis and Prevalence Based on Fasting Glucose and Hemoglobin A1c, Nature Medicine (2023)