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Effect of Curcumin on Oxidative Stress, Inflammatory Response and Kidney Biochemical Parameters Among Kidney Disease Patients: A Systematic Review Publisher



Emami E1 ; Talebiboroujeni P2 ; Sherwin CMT3 ; Heidarisoureshjani S4 ; Mohammadi S5
Authors
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Authors Affiliations
  1. 1. Department of Pediatric Nephrology, Emam Hossein Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cardiology, Chamran Hospital, Isfahan, Iran
  3. 3. Department of Pediatric Clinical Pharmacology, Wright State University Boonshoft School of Medicine, Dayton Children's Hospital, One Children's Plaza, Dayton, OH, United States
  4. 4. Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
  5. 5. Student Research Committee, Department of Obstrics and Gynecology, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Natural Products Journal Published:2023


Abstract

Background: Chronic kidney disease (CKD) and end-stage renal diseases have high global morbidity and mortality. Objective: We aimed to investigate the antioxidant and anti-inflammatory properties of curcumin and its impact on kidney biochemical parameters associated with kidney disease among CKD and hemodialysis (HD) patients. Methods: The intended keywords were used in the literature search. Clinical trial studies from the beginning to December 25th, 2021, indexed in the Institute for Scientific Information (ISI), Scopus, and PubMed databases, were included in the review. Records with no accessible full texts, non-English language articles, and studies that were not related to the study aim were excluded. The agreement for exclusion required all authors to concur. Finally, after reviewing all available literature, 27 articles were included in this systematic review. Results: Curcumin supplementation increased antioxidant capacity by improving catalase (CAT) activity, free radical scavenging activity, and nuclear factor erythroid 2-related factor 2 (Nrf2). It also reduced hs-CRP, IL-6, and TNF-a levels in patients with CKD and HD patients. Different results were reported regarding the effect of curcumin on kidney-related biochemical parameters. But mostly, the results showed that no significant changes were seen in glomerular filtration (GFR), albumin (Alb), serum creatinine (sCr), proteinuria (PRO), and blood urea nitrogen (BUN) in these patients. Conclusion: Although it seems curcumin improved antioxidant capacity and decreased inflammatory cytokines in CKD and HD patients, it did not affect renal biochemical parameters. More clinical studies with larger sample sizes appear to be needed. © 2023 Bentham Science Publishers.
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